Cat. No.: 143 004
Amount: 100 µl
Price:
$365.00
|
|
|
| Cat. No. 143 004 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to AA 939 to 948 from rat Erc1b (UniProt Id: Q811U3-1) |
| Reactivity |
Reacts with: human (Q8IUD2, O15083), rat (Q811U3, Q8K3M6), mouse (Q99MI1, Q6PH08). Other species not tested yet. |
| Specificity | Specific for the brain specific isoforms ERC 1b and ERC 2. |
| Matching control protein/peptide | 143-0P |
| Data sheet | 143_004.pdf |
|
|
ELKS, also referred to as ERCs (ERC 1 and ERC 2) and CAST, are related proteins which share an identical C-terminal sequence. They interact with the conserved RIM PDZ domain via an unusual PDZ binding motif. Two splice variants of ERC 1 (1a and 1b) have been described. ERC 1b (CAST 2a) binds to RIM and is expressed exclusively in the brain. ERC 1a is a ubiquitously expressed cytosolic protein. ERC 2 (CAST 1) is only expressed as a single RIM binding variant.
All ERCs have been shown to interact with Rab 6, a protein involved in membrane trafficking at the Golgi complex. The function of these proteins has not been determined yet. They may link Rab 6 mediated non-neuronal membrane traffic at the Golgi complex to neuronal membrane traffic at the active zone executed via RIMs.