Cat. No.: 122 121
Amount: 100 µl
Price:
$420.00
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| Cat. No. 122 121 |
100 µl hybridoma supernatant, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: 1 : 500 up to 1 : 500 gallery IHC: not recommended IHC-P: not tested yet |
| Clone | 314C5 |
| Subtype | IgM (κ light chain) |
| Immunogen | Recombinant protein corresponding to AA 43 to 91 from mouse Complexin2 (UniProt Id: P84086) |
| Reactivity |
Reacts with: rat (P63041, P84087), mouse (P63040, P84086). Other species not tested yet. |
| Specificity | Recognized complexin 1 and 2 |
| Data sheet | 122_121.pdf |
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Complexins are enriched in neurons where they colocalize with syntaxin 1 and SNAP 25. In addition, complexin 2, also referred to as synaphin 1, is expressed ubiquitously at low levels. Complexins bind weakly to syntaxin 1 alone and not at all to synaptobrevin and SNAP 25, but strongly to the SNAP receptor-core complex composed of these three molecules. They compete with α-SNAP for binding to the core complex but not with other interacting molecules, suggesting that complexins regulate the sequential interactions of α-SNAP and synaptotagmins with the SNAP receptor during exocytosis.
In retinal ribbon synapses complexin 3 and complexin 4 functionally replace complexin 1 (synaphin 2) and 2. They have similar biochemical binding properties and are farnesylated at their C-terminus.