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Home > Products > 262 013

CAPS1 antibody - 262 013 K.O.

CAPS1 is a Ca2+-dependent secretion activator
Rabbit polyclonal purified antibody
Cat. No.: 262 013
Amount: 50 µg
Price: $375.00
Cat. No. 262 013 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (see remarks)
IP: not tested yet
ICC: 1 : 200 up to 1 : 500 gallery  
IHC: not tested yet
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 18 to 107 from mouse CAPS1 (UniProt Id: Q80TJ1)
Reactivity Reacts with: rat (Q62717), mouse (Q80TJ1).
Other species not tested yet.
Specificity Specific for CAPS 1, no cross-reactvity to CAPS 2 K.O. validated PubMed: 25719439
Remarks

WB: Cat. no. 262 003 is recommended for this application.
Data sheet 262_013.pdf

References for CAPS1 - 262 013

Munc13-1 is a Ca2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission.
Lipstein N, Chang S, Lin KH, López-Murcia FJ, Neher E, Taschenberger H, Brose N
Neuron (2021) : . 262 013 WB; tested species: mouse
Paralogs of the Calcium-Dependent Activator Protein for Secretion Differentially Regulate Synaptic Transmission and Peptide Secretion in Sensory Neurons.
Shaib AH, Staudt A, Harb A, Klose M, Shaaban A, Schirra C, Mohrmann R, Rettig J, Becherer U
Frontiers in cellular neuroscience (2018) 12: 304. 262 013 WB, ICC; KO verified; tested species: mouse
RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.
Shumate KM, Tas ST, Kavalali ET, Emeson RB
Journal of neurochemistry (2021) 1582: 182-196. 262 013 ICC; tested species: mouse
Paralogs of the Calcium-Dependent Activator Protein for Secretion Differentially Regulate Synaptic Transmission and Peptide Secretion in Sensory Neurons.
Shaib AH, Staudt A, Harb A, Klose M, Shaaban A, Schirra C, Mohrmann R, Rettig J, Becherer U
Frontiers in cellular neuroscience (2018) 12: 304. 262 013 WB, ICC; KO verified; tested species: mouse
Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.
Geerts CJ, Mancini R, Chen N, Koopmans FTW, Li KW, Smit AB, van Weering JRT, Verhage M, Groffen AJA
PloS one (2017) 127: e0180912. 262 013 ICC; tested species: mouse
CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.
Farina M, van de Bospoort R, He E, Persoon CM, van Weering JR, Broeke JH, Verhage M, Toonen RF
eLife (2015) 4: . 262 013 ICC; KO verified
Cat. No.: 262 013
Amount: 50 µg
Price: $375.00
Munc13-1 is a Ca2+-phospholipid-dependent vesicle priming hub that shapes synaptic short-term plasticity and enables sustained neurotransmission.
Lipstein N, Chang S, Lin KH, López-Murcia FJ, Neher E, Taschenberger H, Brose N
Neuron (2021) : . 262 013 WB; tested species: mouse
Paralogs of the Calcium-Dependent Activator Protein for Secretion Differentially Regulate Synaptic Transmission and Peptide Secretion in Sensory Neurons.
Shaib AH, Staudt A, Harb A, Klose M, Shaaban A, Schirra C, Mohrmann R, Rettig J, Becherer U
Frontiers in cellular neuroscience (2018) 12: 304. 262 013 WB, ICC; KO verified; tested species: mouse
RNA editing-mediated regulation of calcium-dependent activator protein for secretion (CAPS1) localization and its impact on synaptic transmission.
Shumate KM, Tas ST, Kavalali ET, Emeson RB
Journal of neurochemistry (2021) 1582: 182-196. 262 013 ICC; tested species: mouse
Paralogs of the Calcium-Dependent Activator Protein for Secretion Differentially Regulate Synaptic Transmission and Peptide Secretion in Sensory Neurons.
Shaib AH, Staudt A, Harb A, Klose M, Shaaban A, Schirra C, Mohrmann R, Rettig J, Becherer U
Frontiers in cellular neuroscience (2018) 12: 304. 262 013 WB, ICC; KO verified; tested species: mouse
Tomosyn associates with secretory vesicles in neurons through its N- and C-terminal domains.
Geerts CJ, Mancini R, Chen N, Koopmans FTW, Li KW, Smit AB, van Weering JRT, Verhage M, Groffen AJA
PloS one (2017) 127: e0180912. 262 013 ICC; tested species: mouse
CAPS-1 promotes fusion competence of stationary dense-core vesicles in presynaptic terminals of mammalian neurons.
Farina M, van de Bospoort R, He E, Persoon CM, van Weering JR, Broeke JH, Verhage M, Toonen RF
eLife (2015) 4: . 262 013 ICC; KO verified
ICC
Background
The Ca2+-dependent activator protein for secretion (CAPS) regulates exocytosis of catecholamine- or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites.
Two differen isoforms CAPS 1/CADPS 1 and CAPS 2/CADPS 2 that are mainly expressed in brain have been identified in mammals. Both have been shown to be essential components of the synaptic vesicle priming machinery.
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