Cat. No.: 158 002
Amount: 200 µl
Price:
$355.00
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| Cat. No. 158 002 |
200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications |
IP: not tested yet ICC: not tested yet IHC: not tested yet IHC-P: not tested yet |
| Immunogen | Recombinant protein corresponding to AA 1 to 422 from Clostridium botulinum BoNT (UniProt Id: Q00496) |
| Specificity | Specific for BoNT E. |
| Data sheet | 158_002.pdf |
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The neurotoxins of Clostridium botulinum BoNTs belong to the most potent protein toxins. These Zinc proteases elicit paralysis by cleaving SNARE proteins like SNAP 25, Syntaxin 1 and Synaptobrevin which mediate the fusion of synaptic vesicles with the presynaptic membrane.
There are seven known serotypes of BoNTs (A to G) with different cleavage properties. BoNTs are translated as ~150 kDa single-chain, non-toxic precursor proteins which are cleaved into a catalytic light chain (LC) and a heavy translocation chain (HCT).