Cat. No.: 218 711
Amount: 100 µg
Price:
$415.00
|
|
|
| Cat. No. 218 711 |
100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | 88B12 |
| Subtype | IgG2b (κ light chain) |
| Immunogen | Synthetic peptide corresponding to AA 17 to 26 from human Abeta (UniProt Id: P05067) |
| Reactivity |
Reacts with: human (P05067), mouse (P12023). Other species not tested yet. |
| Specificity | Specific for Abeta 38, 40, 42. Due to sequence homology, a cross-reactivity to unprocessed APP cannot be excluded. |
| Remarks |
IHC: Antigen retrieval with formic acid is required. |
| Data sheet | 218_711.pdf |
|
|
Amyloid deposits, also called plaques, of Alzheimer's patients consist of several protein components like the amyloid beta-peptides (Abeta, Aβ) 1-40/42/43 and additional C- and N-terminally modified fragments of Abeta as for instance Abeta pE3 and Abeta pE11.
An additional Abeta variant, Abeta38, is more soluble compared to other Abeta species and is not found in plaques of sporadic Alzheimer´s cases. However, it is detected in the blood-vessel walls of a subset of patients with severe cerebral amyloid angiopathy. It especially accumulates in brains of patients carrying mutations in the Abeta coding region.
Cleavage of amyloid precursor protein APP by β- and γ- secretases results in the generation of the Aβ (βA4)peptide, whereas α-secretase cleaves within the Aβ sequence and prevents the formation of Abeta from APP.