MEF2A antibody - HS-507 003

MEF2A is a member of the MEF2 (myocyte enhancer factor 2) family of transcription factors. The MEF2 family includes three other members, MEF2B, -C and -D. MEF2A is ubiquitously expressed but has an alternatively spliced isoform that is restricted to skeletal muscle, heart and brain due to the inclusion of an exon encoding the peptide SEEEELEL (residues 289-296) (1). The activity of MEF2A can be regulated by phosphorylation/dephosphorylation, which affects its DNA-binding affinity and interaction with transcriptional co-activators and co-repressors. MEF2A is also susceptible to protease cleavage by caspases (2). In neuronal cells, MEF2A plays a role in neurodevelopment and synaptic plasticity. It contributes to the formation and maintenance of neural circuits, ultimately impacting cognitive functions and behavior. MEF2A also has an important role in the immune system. It contributes significantly to the development of T-cells and the immune response. MEF2A is a non-redundant regulator of the inflammatory epigenome of macrophages and, more specifically, of PGE2-sensitive enhancers (3). Defects in MEF2A may be a cause of an autosomal dominant form of coronary artery disease (CAD) with myocardial infarction (ADCAD1) [MIM:608320] (4). MEF2A protein is also regulated in a model of chronic kidney disease using cadmium as a toxic treatment in human proximal tubule cells (HK-2) (5).