Arg-1 antibody - HS-500 023

Arginase-1 (Arg-1) is a cytosolic protein primarily known for its role in the urea cycle within the liver. It has gained increasing attention in the field of immunology due to its significant influence on immune responses and various disease states. Arg-1 converts arginine to urea and ornithine in the last step of the urea cycle in the liver. Arg-1 is expressed in myeloid cells, including macrophages and neutrophils. Its function in the urea pathway plays a crucial role in regulating the production of nitric oxide (NO), a key signaling molecule involved in various immune processes. Arg-1 competes with inducible nitric oxide synthase (iNOS) for arginine, and its activity can skew the immune response towards a more anti-inflammatory or "M2" phenotype in macrophages by limiting NO production (1). Dysregulation of Arg-1 in microglia has been associated with neurodegenerative diseases, such as Alzheimer's and Parkinson's disease (2). An inherited deficiency of this enzyme leads to argininemia, an autosomal recessive disorder characterized by hyperammonemia (3).