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CD206 antibody - HS-488 003

CD206 is a marker of specific macrophage subsets
Rabbit polyclonal purified antibody
Cat. No.: HS-488 003
Amount: 50 µg
Price: $370.00
Cat. No. HS-488 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
WB: 1 : 1000 (AP staining) gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 1000 up to 1 : 2000 gallery  
Immunogen Synthetic peptide corresponding to residues near the carboxy terminus of mouse CD206 (UniProt Id: Q61830)
Reactivity Reacts with: mouse (Q61830), rat, human (P22897).
Other species not tested yet.
Data sheet hs-488_003.pdf
Important information
This product belongs to the HistoSure product line of antibodies developed for and extensively tested in FFPE tissues.
For more information please visit our HistoSure brand website.
Cat. No.: HS-488 003
Amount: 50 µg
Price: $370.00

CD206, also known as macrophage mannose receptor type C (MMR or MRC1), is a member of the C-type lectin (CLEC) family. CD206 is expressed by subpopulations of macrophages, immature dendritic cells, and liver sinusoidal endothelial cells. Its expression level is differentially regulated by cytokines (e.g., IL-10, IL-4, IL-13, and IFNγ), prostaglandins, LPS, and the transcription factor PPAR-γ (1). CD206 functions in endocytosis and phagocytosis (1) and high expression is found both on pro- and antitumor TAMs (tumor-associated macrophages) (2). In the brain, border-associated macrophages (BAMs) can be discriminated from microglia by the expression of CD206 and CD169 (3).