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CD11c antibody - HS-375 017

CD11c is a fibrinogen receptor involved in cell-cell interaction during inflammation
Rat monoclonal purified IgG
Cat. No.: HS-375 017
Amount: 100 µg
Price: $415.00
Cat. No. HS-375 017 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications
 
IHC: 1 : 500 (see remarks) gallery  
IHC-P: 1 : 100 gallery  
Clone SY-322C12
Subtype IgG2b (κ light chain)
Immunogen synthetic peptide corresponding to residues surrounding AA 847 of mouse CD11c (UniProt Id: Q9QXH4)
Reactivity Reacts with: mouse (Q9QXH4).
No signal: rat, human (P20702).
Other species not tested yet.
Specificity Specific for mouse CD11c without cross-reactivity to human CD11c
Remarks

IHC: Heat-mediated antigen retrieval (in citrate buffer pH 6) is required for immunohistochemical stainings

Data sheet hs-375_017.pdf
Important information
This product belongs to the HistoSure product line of antibodies developed for and extensively tested in FFPE tissues.
For more information please visit our HistoSure brand website.
Cat. No.: HS-375 017
Amount: 100 µg
Price: $415.00
Background
CD 11c or Integrin alpha-X (ITGAX) is a heterodimeric glycoprotein consisting of an α- and β-subunit and has seven repeating integrin domains. This transmembrane receptor type I plays a pivotal role in T cell killing and mediates intercellular adhesions during inflammation. Predominat expression levels have been found in dendritic cells, monocytes, macrophages, neutrophils and a small subset of B cells. Under pathological conditions, CD 11c is a marker for hairy cell leukemia, acute non-lymphocytic leukemias, and some chronic lymphocytic leukemias.
Protocols