Neurogenin2 antibody - 530 205

Neurogenins (Ngns) are basic helix-loop-helix (bHLH) transcription factors that play a crucial role in the development of the nervous system and the endocrine pancreas (1, 2). In mammals, the family comprises three members: Neurogenin1 (Ngn1), Neurogenin2 (Ngn2), and Neurogenin3 (Ngn3). Ngn1 and 2 are involved in early stages of neuronal differentiation and promote the transition of neural progenitor cells into neurons and inhibit glial cell formation in a spatially and temporally regulated manner (1, 3).
Additionally, Ngn2 plays a pivotal role in the specification of motor neurons and interneurons in the spinal cord. Phosphorylation of Ngn2 influences its ability to direct the fate of neural progenitors, affecting the balance between different neuronal subtypes (4, 5).
Ngn3 is a pro-endocrine transcription factor, primarily associated with the development of the endocrine pancreas. It is essential for the differentiation of endocrine progenitor cells into various hormone-producing cell types within the islets of Langerhans (2).

• Free floating
• Slide mounted
• Tissue preparation
• Pre-adsorption protocol