Cat. No.: 518 005
Amount: 50 µg
Price:
$460.00
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| Cat. No. 518 005 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to residues near the carboxy region of mouse BCRP1/ABCG2 (UniProt Id: Q7TMS5) |
| Reactivity |
Reacts with: mouse (Q7TMS5). Weaker signal: rat (Q80W57). Other species not tested yet. |
| Data sheet | 518_005.pdf |
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BCRP1/ABCG2 is a heavily glycosylated transmembrane protein with six transmembrane-spanning regions, suggesting a function as a semi-transporter (1).
Neurospheres have been shown to have high levels of BCRP1/ABCG2, and approximately 63% of cells in neurospheres were BCRP1/ABCG2-positive, similar to the proportion of nestin-positive cells, and in most cases BCRP1/ABCG2 and nestin staining were colocalized in the same cells (2). BCRP1/ABCG2 was originally discovered in a multidrug-resistant breast cancer cell line. Past studies have expanded the understanding of its role in physiology, disease pathology, and drug resistance (3). Physiologically, BCRP1/ABCG2 is expressed in barrier organs and tissues including the blood-brain barrier, where BCRP1/ABCG2 localizes at the luminal plasma membrane of endothelial cells and facilitates directional efflux across the blood-brain barrier from brain to blood (4, 5).