Cat. No.: 517 003
Amount: 50 µg
Price:
$375.00
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| Cat. No. 517 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein comprising the extracellular domain of mouse MCAM (UniProt Id: Q8R2Y2) |
| Reactivity |
Reacts with: mouse (Q8R2Y2), rat (Q9EPF2). Other species not tested yet. |
| Remarks |
IHC: Heat-mediated antigen retrieval (citrate buffer pH 6) is recommended |
| Data sheet | 517_003.pdf |
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The melanoma cell adhesion molecule (MCAM, also known as MUC18, CD146, S-endo-1 or P1H12) is a member of the immunoglobulin superfamily that was originally described as a cell surface adhesion protein and marker for the progression and metastasis of melanoma (1,2). Metazoan MCAM has been detected in the majority of cell types, including vasculogenic cells (endothelial, pericytes and smooth muscle cells), epithelia, fibroblasts, mesenchymal stem cells and lymphocytes, with the exception of erythrocytes (3).
MCAM is a strongly glycosylated type I transmembrane protein. On the basis of a bioinformatical analysis, eight putative N-glycosylation sites in the extracellular are present in the extracellular fragment across all species (4).