Cat. No.: 496 004
Amount: 100 µl
Price:
$365.00
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| Cat. No. 496 004 |
100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Synthetic peptide corresponding to residues near the amino terminus of mouse dopamine β-hydroxylase (UniProt Id: Q64237) |
| Reactivity |
Reacts with: rat (Q05754), mouse (Q64237). Other species not tested yet. |
| Specificity | K.O. validated |
| Data sheet | 496_004.pdf |
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The norepinephrine pathway is involved in several behavioral and physiological processes, such as blood pressure, mood, overall arousal, and attention. Abnormalities in this pathway have been linked to several diseases, like hypertension, depression, anxiety, attention deficit hyperactivity disorder, and more (1).
Dopamine β-hydroxylase (DBH), also known as dopamine β-monooxygenase, catalyzes the conversion of dopamine to noradrenaline/norepinephrine (2).
DBH is expressed in noradrenergic neurons of the central nervous system (e.g.locus coeruleus), the peripheral nervous system (e.g. sympathetic ganglia) (3) and by chromaffin cells in large dense core vesicles (LDCVs) of the adrenal medulla (3, 4).