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TARP-gamma8 antibody - 478 003

TARPs are GluA interacting proteins
Rabbit polyclonal purified antibody
Cat. No.: 478 003
Amount: 50 µg
Price: $375.00
Cat. No. 478 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 2000 up to 1 : 5000 (AP-staining) gallery  
IP: not tested yet
ICC: 1 : 500 up to 1 : 5000 gallery  
IHC: 1 : 1000 up to 1 : 3000 gallery  
IHC-P: 1 : 1000 gallery  
Immunogen Recombinant protein corresponding to residues near the carboxy terminus of mouse TARP-γ8. (UniProt Id: Q8VHW2)
Reactivity Reacts with: mouse (Q8VHW2), rat (Q8VHW5).
Other species not tested yet.
Data sheet 478_003.pdf

References for TARP-gamma8 - 478 003

In vitro evaluation of PET radiotracers for imaging synaptic density, the acetylcholine transporter, AMPA-tarp-γ8 and muscarinic M4 receptors in Alzheimer's disease.
d'Orchymont F, Narvaez A, Raymond R, Sachdev P, Charil A, Krause S, Vasdev N
American journal of nuclear medicine and molecular imaging (2024) 141: 1-12. 478 003 ; tested species: human
Cat. No.: 478 003
Amount: 50 µg
Price: $375.00
In vitro evaluation of PET radiotracers for imaging synaptic density, the acetylcholine transporter, AMPA-tarp-γ8 and muscarinic M4 receptors in Alzheimer's disease.
d'Orchymont F, Narvaez A, Raymond R, Sachdev P, Charil A, Krause S, Vasdev N
American journal of nuclear medicine and molecular imaging (2024) 141: 1-12. 478 003 ; tested species: human
Background

Ligand gated cation channels of the AMPA subtype are composed of different GluA subunits and interact with a family of proteins termed transmembrane AMPA-receptor regulatory proteins (TARPs) also known as voltage gated calcium channel gamma subunits or CNAGs (1). These proteins regulate the surface expression and biophysical properties like the gating time of AMPA glutamate receptors (1). Six transmembrane AMPA receptor regulatory protein (TARP) isoforms, classified as Type I (γ-2, -3, -4, and -8) and Type II (γ-5 and -7), are discretely expressed in specific neuronal and glial populations and differentially regulate synaptic transmission throughout the brain (2). One key feature of TARP-gamma2 and TARP-gamma8 is the differential regulation of synaptic strength in the hippocampus that is determined by the number and density of AMPA glutamate receptors (3).
Especially, TARP-gamma8 shows high expression levels in the hippocampus and is only sparsely expressed in other brain areas (4).
The TARP-gamma3 gene locus shows a linkage to childhood absence epilepsy (CAE) (5).