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Tarp-gamma8 antibody - 478 003

Tarps are GluA interacting proteins
Rabbit polyclonal purified antibody
Cat. No.: 478 003
Amount: 50 µg
Price: $370.00
Cat. No. 478 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
WB: 1 : 2000 up to 1 : 5000 (AP-staining) gallery  
IP: not tested yet
ICC: 1 : 500 up to 1 : 5000 gallery  
IHC: 1 : 1000 up to 1 : 3000 gallery  
IHC-P: yes gallery  
Immunogen Recombinant protein corresponding to residues near the carboxy terminus of mouse Tarp-γ8. (UniProt Id: Q8VHW2)
Reactivity Reacts with: mouse (Q8VHW2), rat (Q8VHW5).
Other species not tested yet.
Specificity Specific for Tarp-gamma8
Data sheet 478_003.pdf
Cat. No.: 478 003
Amount: 50 µg
Price: $370.00

Ligand gated cation channels of the AMPA subtype are composed of different GluA subunits and interact with a family of proteins termed transmembrane AMPA-receptor regulatory proteins (TARPs) (1). These proteins regulate the surface expression and biophysical properties like the gating time of AMPA glutamate receptors (1). One key feature of Tarp-gamma2 and Tarp-gamma8 is the differential regulation of synaptic strength in the hippocampus that is determined by the number and density of AMPA glutamate receptors (2).
Especially, Tarp-gamma8 shows high expression levels in the hippocampus and is only sparsely expressed in other brain areas (3).