Cat. No.: 475 002
Amount: 200 µl
Price:
$355.00
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| Cat. No. 475 002 |
200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Full length mouse recombinant CaBP 5 (UniProt Id: D3ZW89) |
| Reactivity |
Reacts with: mouse (Q9JLK3), rat (D3ZW89). Other species not tested yet. |
| Specificity | Due to sequence homology, the antibody may exhibit some cross-reactivity to CaBP1, 2, 3 and 4. |
| Remarks |
IHC: Brief immersion fixation of retina samples give best results. For over night fixed tissues, a heat mediated antigen retrieval (AGR) step is recommended. |
| Data sheet | 475_002.pdf |
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Calcium binding protein 5 (CaBP 5) belongs to a subfamiliy of neuronal Ca2+ binding proteins (CaBP 1-5) that show a high similarity to Calmodulin (1).
It is expressed in rod and cone bipolar cells of the retina (1) and cochlea inner hair cells of the ear (2).
CaBPs are involved in the modulation of voltage gated calcium channels, TRP channels and inositol1,4,5-triphosphate (IP3) receptors (2).
A CaBP 5 K.O. model suggests that this Ca-binding protein is involved in the rod-mediated response across the retina (3).