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CaBP 5 antibody - 475 002

CaBP5 is retina specific calcium binding protein
Rabbit polyclonal antiserum
Cat. No.: 475 002
Amount: 200 µl
Price: $350.00
Cat. No. 475 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications
 
WB: 1 : 1000 (AP-staining) gallery  
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 up to 1 : 10000 (see remarks) gallery  
IHC-P: not tested yet
Immunogen Full length mouse recombinant CaBP 5 (UniProt Id: D3ZW89)
Reactivity Reacts with: mouse (Q9JLK3), rat (D3ZW89).
Other species not tested yet.
Specificity Due to sequence homology, the antibody may exhibit some cross-reactivity to CaBP1, 2, 3 and 4.
Remarks

IHC: Brief immersion fixation of retina samples give best results. For over night fixed tissues, a heat mediated antigen retrieval (AGR) step is recommended.

Data sheet 475_002.pdf
Cat. No.: 475 002
Amount: 200 µl
Price: $350.00
Background

Calcium binding protein 5 (CaBP 5) belongs to a subfamiliy of neuronal Ca2+ binding proteins (CaBP 1-5) that show a high similarity to Calmodulin (1).
It is expressed in rod and cone bipolar cells of the retina (1) and cochlea inner hair cells of the ear (2).
CaBPs are involved in the modulation of voltage gated calcium channels, TRP channels and inositol1,4,5-triphosphate (IP3) receptors (2).
A CaBP 5 K.O. model suggests that this Ca-binding protein is involved in the rod-mediated response across the retina (3).