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Substance P antibody - 459 005

Substance P is a neuropeptide involved in intestinal contraction, neurogenic inflammation and pain processing
Polyclonal Guinea pig purified antibody
Cat. No.: 459 005
Amount: 50 µg
Price: $450.00
Cat. No. 459 005 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery  
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 58 to 68 from mouse Protachykinin-1 (UniProt Id: P41539)
Reactivity Reacts with: mouse (P41539), rat (P06767).
Other species not tested yet.
Specificity The antibody is specific for substance P. It shows no cross-reactivity to neurokinin A, neurokinin B, or the unprocessed precursor protein.
Data sheet 459_005.pdf
Cat. No.: 459 005
Quantity: 50 µg
Price: $450.00
Background

Substance P (also designated SP or NK-1) is a highly conserved peptide that was originally discovered in 1931 (1). It is an undecapeptide belonging to the tachykinin neuropeptide family. Mammalian tachykinins include substance P, neurokinin A and neurokinin B, and they all share the same carboxy-terminal amino acid sequence (2,3).
Substance P is generated by post-translational cleavage of the precursor Protachykinin-1 (2,3).
Substance P is widely distributed throughout the central and peripheral nervous system, including the brain, spinal cord, and nerve fibers and endocrine cells of the gastrointestinal tract (3,4).
Substance P exerts its effects by binding to the neurokinin-1 receptor NK-1R (2,3).
It functions in the central and peripheral nervous systems as a neurotransmitter or neuromodulator (5) and is involved in many biological processes, including intestinal smooth muscle contraction, blood pressure regulation, neurogenic inflammation, nociception and pain transmission (2,5). Furthermore, it has gained attention for its role in complex psychiatric processes including stress, anxiety, and depression (2).