|Cat. No. 457 005||50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: 1 : 1000 up to 1 : 2000 (AP staining) gallery
ICC: 1 : 500 up to 1 : 1000 gallery
IHC: 1 : 500 up to 1 : 1000 gallery
IHC-P/FFPE: 1 : 500 up to 1 : 1000 gallery
|Immunogen||Recombinant protein corresponding to AA 52 to 143 from mouse Opalin (UniProt Id: Q7M750)|
Reacts with: mouse (Q7M750), rat (Q56A26), human (Q96PE5).
Other species not tested yet.
|Specificity||Specific for Opalin|
Opalin also called Tmem10 is a transmembrane protein detected specifically in mammalian oligodendrocytes. Opalin homologs are found only in mammals and not in the genome sequences of other animal classes (1). Deficient mice are born the expected Mendelian ratio and have a normal body shape and weight. No obvious abnormalities in gross anatomy or major myelin protein components nor in the compartment of myelinated axons and oligodendrocyte maturation. Nevertheless, deficient mice display increased exploratory activity in a novel environment (2).