Cat. No.: 445 008
Amount: 50 µg
Price:
$420.00
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| Cat. No. 445 008 |
50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | Rb203G7 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Synthetic peptide corresponding to residues near the C-terminus of mouse BCAS1 (UniProt Id: Q80YN3) |
| Reactivity |
Reacts with: mouse (Q80YN3), rat (Q3ZB98). No signal: human (O75363). Other species not tested yet. |
| Specificity | Antibody detects mouse BCAS1 isoforms with uniprot IDs Q80YN3, E9Q8Q5 and A2AVX1. It does not detect isoform F7BNZ5. It detects rat isoforms Q3ZB98-1 and -5 and is negative for isoform -2, -3, -4 and 6. |
| Remarks |
This antibody is a chimeric antibody based on the monoclonal mouse antibody SY-203G7. The constant regions of the heavy and light chains have been replaced with rabbit specific sequences. The antibody can therefore be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells. |
| Data sheet | 445_008.pdf |
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Breast carcinoma-amplified sequence 1 (BCAS1) was originally identified as a potential oncogene amplified in human cancer cell lines (1). It is also highly expressed in brain (2) where it mainly defines an oligodendroglial subpopulation occuring at regions of active myelin formation (3).
In fetal brain BCAS1 positive oligodendrocytes are restricted to the white matter. In adult brains they persist in the grey matter until old age (3).