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BCAS1 antibody - 445 008

BCAS1 is a protein specific for an actively myelinating oligodendrocyte subpopulation
Rabbit monoclonal recombinant IgG
Cat. No.: 445 008
Amount: 50 µg
Price: $415.00
Cat. No. 445 008 50 µg purified recombinant IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not recommended
IP: not tested yet
ICC: 1 : 500 up to 1 : 2000 gallery  
IHC: 1 : 1000 up to 1 : 5000 gallery  
IHC-P: 1 : 1000 gallery  
Clone Rb203G7
Subtype IgG1 (κ light chain)
Immunogen Synthetic peptide corresponding to residues near the C-terminus of mouse BCAS1 (UniProt Id: Q80YN3)
Reactivity Reacts with: mouse (Q80YN3), rat (Q3ZB98).
No signal: human (O75363).
Other species not tested yet.
Specificity Antibody detects mouse BCAS1 isoforms with uniprot IDs Q80YN3, E9Q8Q5 and A2AVX1. It does not detect isoform F7BNZ5. It detects rat isoforms Q3ZB98-1 and -5 and is negative for isoform -2, -3, -4 and 6.
Remarks

This antibody is a chimeric antibody based on the monoclonal mouse antibody SY-203G7. The constant regions of the heavy and light chains have been replaced with rabbit specific sequences. The antibody can therefore be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells.

Data sheet 445_008.pdf
Cat. No.: 445 008
Amount: 50 µg
Price: $415.00
Background

Breast carcinoma-amplified sequence 1 (BCAS1) was originally identified as a potential oncogene amplified in human cancer cell lines (1). It is also highly expressed in brain (2) where it mainly defines an oligodendroglial subpopulation occuring at regions of active myelin formation (3).
In fetal brain BCAS1 positive oligodendrocytes are restricted to the white matter. In adult brains they persist in the grey matter until old age (3).