|Cat. No. 417 003||50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: 1 : 1000 AP-staining gallery
IP: not tested yet
ICC: 1 : 500 gallery
IHC: not tested yet
IHC-P/FFPE: not tested yet
|Immunogen||Recombinant protein corresponding to AA 2 to 118 from mouse METTL3 (UniProt Id: Q8C3P7)|
Reacts with: mouse (Q8C3P7), human (Q86U44).
Other species not tested yet.
|Specificity||Specific for isoform 1 K.D. PubMed: 34108665|
The METTL3-METTL14 heterodimer forms a N6-methyltransferase complex that methylates adenosine residues of RNAs at the 5'-[AG]GAC-3' consensus sites. N6-methyladenosine (m6A) has been shown to function as an important regualtory element in many processes like the circadian clock, differentiation of embryonic stem cells, primary miRNA processing, mRNA splicing, translation efficiency, mRNA editing and stability.