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Brn 3a - 411 003

A transcription factor involved in neuronal development
Polyclonal rabbit purified antibody
Cat. No.: 411 003
Amount: 50 µg
Price: $370.00
Cat. No. 411 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 1000 up to 1 : 5000 gallery  
IHC-P/FFPE: 1 : 500 up to 1 : 1000 gallery  
Immunogen Synthetic peptide corresponding to AA 7 to 28 from mouse Brn3a (UniProt Id: P17208)
Reactivity Reacts with: mouse (P17208).
Other species not tested yet.
Specificity Specific for Brn3a.
Data sheet 411_003.pdf

References for Brn 3a - 411 003

Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived Nociceptors.
Schoepf CL, Zeidler M, Spiecker L, Kern G, Lechner J, Kummer KK, Kress M
Brain sciences (2020) 106: . 411 003 ICC; tested species: human,mouse
Neuroprotection mediated by ST266 requires full complement of proteins secreted by amnion-derived multipotent progenitor cells.
Willett K, Khan RS, Dine K, Wessel H, Kirshner ZZ, Sauer JL, Ellis A, Brown LR, Shindler KS
PloS one (2021) 161: e0243862. 411 003 IHC; tested species: mouse
Oral administration of the iron chelator deferiprone protects against loss of retinal ganglion cells in a mouse model of glaucoma.
Cui QN, Bargoud AR, Ross AG, Song Y, Dunaief JL
Experimental eye research (2020) : 107961. 411 003 IHC; tested species: mouse
SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice.
Luo J, He T, Yang J, Yang N, Li Z, Xing Y
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2020) 2582: 335-344. 411 003 IHC; tested species: mouse
One proline deletion in the fusion peptide of neurotropic mouse hepatitis virus (MHV) restricts retrograde axonal transport and neurodegeneration.
Rout SS, Singh M, Shindler KS, Das Sarma J
The Journal of biological chemistry (2020) 29520: 6926-6935. 411 003 IHC; tested species: mouse
Amnion-Derived Multipotent Progenitor Cells Suppress Experimental Optic Neuritis and Myelitis.
Khan RS, Ross AG, Willett K, Dine K, Banas R, Brown LR, Shindler KS
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2020) : . 411 003 IHC; tested species: mouse
Mapping of Extrinsic Innervation of the Gastrointestinal Tract in the Mouse Embryo.
Niu X, Liu L, Wang T, Chuan X, Yu Q, Du M, Gu Y, Wang L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4035: 6691-6708. 411 003 IHC; tested species: mouse
GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension.
Sterling JK, Adetunji MO, Guttha S, Bargoud AR, Uyhazi KE, Ross AG, Dunaief JL, Cui QN
Cell reports (2020) 335: 108271. 411 003 IHC; tested species: mouse
Cat. No.: 411 003
Quantity: 50 µg
Price: $370.00
Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived Nociceptors.
Schoepf CL, Zeidler M, Spiecker L, Kern G, Lechner J, Kummer KK, Kress M
Brain sciences (2020) 106: . 411 003 ICC; tested species: human,mouse
Neuroprotection mediated by ST266 requires full complement of proteins secreted by amnion-derived multipotent progenitor cells.
Willett K, Khan RS, Dine K, Wessel H, Kirshner ZZ, Sauer JL, Ellis A, Brown LR, Shindler KS
PloS one (2021) 161: e0243862. 411 003 IHC; tested species: mouse
Oral administration of the iron chelator deferiprone protects against loss of retinal ganglion cells in a mouse model of glaucoma.
Cui QN, Bargoud AR, Ross AG, Song Y, Dunaief JL
Experimental eye research (2020) : 107961. 411 003 IHC; tested species: mouse
SIRT1 is required for the neuroprotection of resveratrol on retinal ganglion cells after retinal ischemia-reperfusion injury in mice.
Luo J, He T, Yang J, Yang N, Li Z, Xing Y
Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie (2020) 2582: 335-344. 411 003 IHC; tested species: mouse
One proline deletion in the fusion peptide of neurotropic mouse hepatitis virus (MHV) restricts retrograde axonal transport and neurodegeneration.
Rout SS, Singh M, Shindler KS, Das Sarma J
The Journal of biological chemistry (2020) 29520: 6926-6935. 411 003 IHC; tested species: mouse
Amnion-Derived Multipotent Progenitor Cells Suppress Experimental Optic Neuritis and Myelitis.
Khan RS, Ross AG, Willett K, Dine K, Banas R, Brown LR, Shindler KS
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics (2020) : . 411 003 IHC; tested species: mouse
Mapping of Extrinsic Innervation of the Gastrointestinal Tract in the Mouse Embryo.
Niu X, Liu L, Wang T, Chuan X, Yu Q, Du M, Gu Y, Wang L
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 4035: 6691-6708. 411 003 IHC; tested species: mouse
GLP-1 Receptor Agonist NLY01 Reduces Retinal Inflammation and Neuron Death Secondary to Ocular Hypertension.
Sterling JK, Adetunji MO, Guttha S, Bargoud AR, Uyhazi KE, Ross AG, Dunaief JL, Cui QN
Cell reports (2020) 335: 108271. 411 003 IHC; tested species: mouse
Background

Brn 3a, also referred to as POU4F1, RGC-1 or Oct-T1, is a transcription factor highly expressed in the developing peripheral sensory nervous system, in cells of the B- and T-lymphocytic lineages and in certain regions of the CNS e.g. retina, spinal cord, midbrain superior colliculus, red nucleus, nucleus ambiguus, inferior olivary nucleus and habenula. In the retina Brn3a is a well-established marker for retinal ganglion cells.