|Cat. No. 408 004||100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.|
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery
IHC-P/FFPE: 1 : 500 up to 1 : 750 gallery
|Immunogen||Synthetic peptide corresponding to AA 20 to 28 from mouse Oxytocin-neurophysin1 (UniProt Id: P35454)|
Reacts with: mouse (P35454), rat (P01179).
Other species not tested yet.
|Specificity||The antibody recognizes Oxytocin. It may crossreact with the unprocessed precursor protein.|
Oxytocin is a peptide hormone which is synthesized as an inactive precursor in nerve cell bodies in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. The precursor protein is progressively hydrolyzed to produce oxytocin and its carrier protein neurophysin I. Together with neurophysin I, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis, where it is either stored or secreted into the bloodstream.
Oxytocin is also produced by some neurons of the hypothalamus that project to other parts of the brain and to the spinal cord.
Oxytocin is best known for roles in female reproduction as its release causes smooth muscle contraction during parturition and lactation. It is also involved in cognition, tolerance, adaptation, and complex sexual and maternal behavior.
Oxytocin is used as a medication to facilitate childbirth.