|Cat. No. 406 003||50 µg specific antibody, lyophilized. Affinity purified with the immunogen. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 100 gallery
IHC-P/FFPE: 1 : 200 up to 1 : 1000 gallery
|Immunogen||Synthetic peptide corresponding to AA 333 to 349 from mouse Islet1 (UniProt Id: P61372)|
Reacts with: mouse (P61372), rat (P61374).
Other species not tested yet.
|Specificity||The antibody may crossreact with Islet-2 due to sequence homology.|
Islet-1 (Isl1) is a member of the LIM/homeodomain family of transcription factors. It binds and regulates the promoters of the insulin, glucagon and somatostatin genes, and may play an important role in regulating insulin gene expression. It is central to the embryogenesis of pancreatic islets of Langerhans and is involved in the specification of motor neurons. It is expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, and in inner nuclear and ganglion cell layers in the retina.
Isl1 is essential for heart development, as its expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry.
Mutations in this gene have been associated with maturity-onset diabetes of the young.