Home|||||||Technical Support|

Islet-1 - 406 003

A LIM/homeodomain containing transcription factor involved in embryogenesis.
Polyclonal rabbit purified antibody
Cat. No.: 406 003
Amount: 50 µg
Price: $370.00
Cat. No. 406 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 100 gallery  
IHC-P/FFPE: 1 : 200 up to 1 : 1000 gallery  
Immunogen Synthetic peptide corresponding to AA 333 to 349 from mouse Islet1 (UniProt Id: P61372)
Reactivity Reacts with: mouse (P61372), rat (P61374).
Other species not tested yet.
Specificity The antibody may crossreact with Islet-2 due to sequence homology.
Data sheet 406_003.pdf

References for Islet-1 - 406 003

Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived Nociceptors.
Schoepf CL, Zeidler M, Spiecker L, Kern G, Lechner J, Kummer KK, Kress M
Brain sciences (2020) 106: . 406 003 ICC; tested species: human,mouse
Cat. No.: 406 003
Quantity: 50 µg
Price: $370.00
Selected Ionotropic Receptors and Voltage-Gated Ion Channels: More Functional Competence for Human Induced Pluripotent Stem Cell (iPSC)-Derived Nociceptors.
Schoepf CL, Zeidler M, Spiecker L, Kern G, Lechner J, Kummer KK, Kress M
Brain sciences (2020) 106: . 406 003 ICC; tested species: human,mouse
Background

Islet-1 (Isl1) is a member of the LIM/homeodomain family of transcription factors. It binds and regulates the promoters of the insulin, glucagon and somatostatin genes, and may play an important role in regulating insulin gene expression. It is central to the embryogenesis of pancreatic islets of Langerhans and is involved in the specification of motor neurons. It is expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, and in inner nuclear and ganglion cell layers in the retina.
Isl1 is essential for heart development, as its expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry.
Mutations in this gene have been associated with maturity-onset diabetes of the young.