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LAMP3 antibody - 391 005

LAMP3 is a glycoprotein of the lysosomal membrane
Guinea pig polyclonal purified antibody
Cat. No.: 391 005
Amount: 50 µg
Price: $450.00
Cat. No. 391 005 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications
 
WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: 1 : 200 up to 1 : 5000      gallery  
Immunogen Synthetic peptide corresponding to AA 404 to 411 from mouse LAMP3 (UniProt Id: Q7TST5)
Reactivity Reacts with: mouse (Q7TST5), rat (Q5XI99).
No signal: human.
Other species not tested yet.
Specificity Recognizes LAMP 3, no crossreactivity to LAMP 1, LAMP 2 and LAMP 5.
Data sheet 391_005.pdf

References for LAMP3 - 391 005

Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo.
Little DR, Lynch AM, Yan Y, Akiyama H, Kimura S, Chen J
Nature communications (2021) 121: 2509. 391 005 IHC; tested species: mouse
Multi-lineage Lung Regeneration by Stem Cell Transplantation across Major Genetic Barriers.
Hillel-Karniel C, Rosen C, Milman-Krentsis I, Orgad R, Bachar-Lustig E, Shezen E, Reisner Y
Cell reports (2020) 303: 807-819.e4. 391 005 IHC; tested species: mouse
Cat. No.: 391 005
Amount: 50 µg
Price: $450.00
Differential chromatin binding of the lung lineage transcription factor NKX2-1 resolves opposing murine alveolar cell fates in vivo.
Little DR, Lynch AM, Yan Y, Akiyama H, Kimura S, Chen J
Nature communications (2021) 121: 2509. 391 005 IHC; tested species: mouse
Multi-lineage Lung Regeneration by Stem Cell Transplantation across Major Genetic Barriers.
Hillel-Karniel C, Rosen C, Milman-Krentsis I, Orgad R, Bachar-Lustig E, Shezen E, Reisner Y
Cell reports (2020) 303: 807-819.e4. 391 005 IHC; tested species: mouse
Background
LAMP 3 (lysosome-associated membrane glycoprotein 3), also referred to as DC-LAMP (dendritic cell LAMP) or CD 208, is a member of the LAMP protein family and a single-pass type I transmembrane protein that can be variably glycosylated. It is specifically expressed in lung type II pneumocytes and by activated human dendritic cells.
Recent studies demonstrated high expression of LAMP 3 in a variety of malignancies including squamous cell carcinoma, gastrointestinal cancer, breast cancer, ovarian cancer, and cervical cancer. Its expression has been associated with hypoxia-induced metastasis and poor overall survival.