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TRIM 46 antibody - 377 008

TRIM46 is involved in establishing neuronal polarity
Monoclonal Recombinant rabbit purified IgG
Cat. No.: 377 008
Amount: 50 µg
Price: $415.00
Cat. No. 377 008 50 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 1000 gallery  
IHC-P/FFPE: 1 : 1000 gallery  
Clone Rb264D12
Subtype IgG1 (κ light chain)
Immunogen Recombinant protein corresponding to AA 1 to 561 from rat Trim46 (UniProt Id: A0A0G2JXN2)
Reactivity Reacts with: mouse (Q7TNM2), rat (A0A0G2JXN2).
Other species not tested yet.
Specificity Specific for TRIM 46
Remarks

This antibody is a chimeric antibody based on the monoclonal mouse antibody clone 264D12. The constant regions of the heavy and light chains have been replaced by rabbit specific sequences. Therefore, the antibody can be used with standard anti-rabbit secondary reagents. The antibody has been expressed in mammalian cells.

Data sheet 377_008.pdf
Cat. No.: 377 008
Quantity: 50 µg
Price: $415.00
Background
The tripartite motif containing protein TRIM 46, also referred to as TRIFIC, is a member of the C-I TRIM family, a subfamily of the RBCC (N-terminal RING finger/B-box/coiled coil)/TRIM superfamily.
TRIM 46 localizes to newly specified axons and, at later stages, to the axon initial segment (AIS). By forming closely spaced parallel microtubule bundles it plays a crucial role in the initial polarization of neuronal cells.