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CAML antibody - 359 004

CAML is a receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins
Polyclonal Guinea pig antiserum
Cat. No.: 359 004
Amount: 100 µl
Price: $350.00
Cat. No. 359 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 1 to 187 from mouse CAML (UniProt Id: P49070)
Reactivity Reacts with: rat (Q6DGG9), mouse (P49070).
Other species not tested yet.
Specificity Specific for CAML.
Data sheet 359_004.pdf

References for CAML - 359 004

A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science (2019) 13213: . 359 004 WB; tested species: human
Cat. No.: 359 004
Quantity: 100 µl
Price: $350.00
A trap mutant reveals the physiological client spectrum of TRC40.
Coy-Vergara J, Rivera-Monroy J, Urlaub H, Lenz C, Schwappach B
Journal of cell science (2019) 13213: . 359 004 WB; tested species: human
Background

The integral membrane protein CAML (Calcium signal-modulating cyclophilin ligand) is highly conserved throughout species and constitutively expressed in immune cells and various cells of the nervous system. Besides its link to calcium signaling, it has recently been shown that CAML reconstitutes together with WRB the TRC40 receptor at the endoplasmic reticulum, which mediates post-translationally insertion of tail-anchored membrane proteins into the ER.