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CAML antibody - 359 002

CAML is a receptor for TRC40/Asna1-mediated insertion of tail-anchored proteins
Polyclonal rabbit antiserum
Cat. No.: 359 002
Amount: 200 µl
Price: $350.00
Cat. No. 359 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: not tested yet
IHC: not tested yet
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 1 to 187 from mouse CAML (UniProt Id: P49070)
Reactivity Reacts with: rat (Q6DGG9), mouse (P49070).
Other species not tested yet.
Specificity Specific for CAML.
Data sheet 359_002.pdf

References for CAML - 359 002

Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex.
Inglis AJ, Page KR, Guna A, Voorhees RM
Cell reports (2020) 3011: 3691-3698.e5. 359 002 WB; tested species: human
Cat. No.: 359 002
Quantity: 200 µl
Price: $350.00
Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex.
Inglis AJ, Page KR, Guna A, Voorhees RM
Cell reports (2020) 3011: 3691-3698.e5. 359 002 WB; tested species: human
Background

The integral membrane protein CAML (Calcium signal-modulating cyclophilin ligand) is highly conserved throughout species and constitutively expressed in immune cells and various cells of the nervous system. Besides its link to calcium signaling, it has recently been shown that CAML reconstitutes together with WRB the TRC40 receptor at the endoplasmic reticulum, which mediates post-translationally insertion of tail-anchored membrane proteins into the ER.