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Home > Products > 355 004

CNP1 antibody - 355 004 K.O.

CNP1 is a marker for oligodendrocytes
Guinea pig polyclonal antiserum
Cat. No.: 355 004
Amount: 100 µl
Price: $365.00
Cat. No. 355 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.
Immunogen Recombinant protein corresponding to AA 1 to 420 from mouse CNP1 (UniProt Id: P16330)
Reactivity Reacts with: rat, mouse.
Other species not tested yet.
Specificity K.O. validated
Data sheet 355_004.pdf

References for CNP1 - 355 004

Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice.
Chapman TW, Olveda GE, Bame X, Pereira E, Hill RA
Nature neuroscience (2023) 264: 555-569. 355 004 IHC; tested species: mouse
Regionally Altered Immunosignals of Surfactant Protein-G, Vascular and Non-Vascular Elements of the Neurovascular Unit after Experimental Focal Cerebral Ischemia in Mice, Rats, and Sheep.
Michalski D, Reimann W, Spielvogel E, Mages B, Biedermann B, Barthel H, Nitzsche B, Schob S, Härtig W
International journal of molecular sciences (2022) 2311: . 355 004 IHC; tested species: mouse
Increased Immunosignals of Collagen IV and Fibronectin Indicate Ischemic Consequences for the Neurovascular Matrix Adhesion Zone in Various Animal Models and Human Stroke Tissue.
Michalski D, Spielvogel E, Puchta J, Reimann W, Barthel H, Nitzsche B, Mages B, Jäger C, Martens H, Horn AKE, Schob S, et al.
Frontiers in physiology (2020) 11: 575598. 355 004 IHC; tested species: mouse
Simultaneous alterations of oligodendrocyte-specific CNP, astrocyte-specific AQP4 and neuronal NF-L demarcate ischemic tissue after experimental stroke in mice.
Mages B, Aleithe S, Blietz A, Krueger M, Härtig W, Michalski D
Neuroscience letters (2019) : 134405. 355 004 IHC; tested species: mouse
Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits.
Platt RJ, Zhou Y, Slaymaker IM, Shetty AS, Weisbach NR, Kim JA, Sharma J, Desai M, Sood S, Kempton HR, Crabtree GR, et al.
Cell reports (2017) 192: 335-350. 355 004 IHC; tested species: mouse
Cat. No.: 355 004
Amount: 100 µl
Price: $365.00
Oligodendrocyte death initiates synchronous remyelination to restore cortical myelin patterns in mice.
Chapman TW, Olveda GE, Bame X, Pereira E, Hill RA
Nature neuroscience (2023) 264: 555-569. 355 004 IHC; tested species: mouse
Regionally Altered Immunosignals of Surfactant Protein-G, Vascular and Non-Vascular Elements of the Neurovascular Unit after Experimental Focal Cerebral Ischemia in Mice, Rats, and Sheep.
Michalski D, Reimann W, Spielvogel E, Mages B, Biedermann B, Barthel H, Nitzsche B, Schob S, Härtig W
International journal of molecular sciences (2022) 2311: . 355 004 IHC; tested species: mouse
Increased Immunosignals of Collagen IV and Fibronectin Indicate Ischemic Consequences for the Neurovascular Matrix Adhesion Zone in Various Animal Models and Human Stroke Tissue.
Michalski D, Spielvogel E, Puchta J, Reimann W, Barthel H, Nitzsche B, Mages B, Jäger C, Martens H, Horn AKE, Schob S, et al.
Frontiers in physiology (2020) 11: 575598. 355 004 IHC; tested species: mouse
Simultaneous alterations of oligodendrocyte-specific CNP, astrocyte-specific AQP4 and neuronal NF-L demarcate ischemic tissue after experimental stroke in mice.
Mages B, Aleithe S, Blietz A, Krueger M, Härtig W, Michalski D
Neuroscience letters (2019) : 134405. 355 004 IHC; tested species: mouse
Chd8 Mutation Leads to Autistic-like Behaviors and Impaired Striatal Circuits.
Platt RJ, Zhou Y, Slaymaker IM, Shetty AS, Weisbach NR, Kim JA, Sharma J, Desai M, Sood S, Kempton HR, Crabtree GR, et al.
Cell reports (2017) 192: 335-350. 355 004 IHC; tested species: mouse
WB
WB
ICC
IHC
IHC-P
Background
The 2', 3'-cyclic nucleotide 3'-phosphodiesterase CNP 1, also referred to as CNPase and CNP, is one of the most abundant membrane-associated enzymes in the myelin sheath of the vertebrate nervous system.
It is assumed that CNP 1 participates in RNA metabolism of myelinating oligodendrocytes.
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