Tailor-made Antibodies
and Tools for Life Science
Home|||||Technical Support

Torsin A antibody - 337 003

TorsinA is a protein involved in DYT1 dystonia
Rabbit polyclonal purified antibody
Cat. No.: 337 003
Amount: 50 µg
Price: $375.00
Cat. No. 337 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: not tested yet
ICC: not tested yet
IHC: not recommended
IHC-P: not tested yet

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.

Immunogen Synthetic peptide corresponding to AA 320 to 332 from human TorsinA (UniProt Id: O14656)
Reactivity Reacts with: human (O14656), rat (Q68G38), mouse (Q9ER39).
Other species not tested yet.
Matching control protein/peptide 337-0P
Data sheet 337_003.pdf
Cat. No.: 337 003
Amount: 50 µg
Price: $375.00
Background
Torsins are members of the AAA+ superfamily of ATPases which are associated with a variety of cellular activities and are present in all multicellular organisms. They are chaperone-like proteins, involved in protein trafficking, membrane fusion and participating in secretory processing. Torsins are also involved in neurogenesis, neuronal migration, axon/dendrite development and synaptogenesis.
A C-terminal codon deletion in Torsin A, also named Torsin 1A, is associated with inherited DYT1 dystonia.