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Doublecortin - 326 003

A protein associated with neuronal differentiation
Polyclonal rabbit purified antibody
Cat. No.: 326 003
Amount: 50 µg
Price: 370.00 €
Cat. No. 326 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: not tested yet
IHC: 1 : 200 up to 1 : 500 gallery  
IHC-P/FFPE: 1 : 200 up to 1 : 500 gallery  
Immunogen Recombinant protein corresponding to AA 271 to 366 from mouse Doublecortin (UniProt Id: Q6PGI2)
Reactivity Reacts with: rat (Q9ESI7), mouse (Q6PGI2), human (O43602).
Other species not tested yet.
Specificity Specific for doublecortin.
Data sheet 326_003.pdf

References for Doublecortin - 326 003

A Citrus based sensory functional food ingredient induces antidepressant-like effects: possible involvement of an interplay between the olfactory and the serotonergic systems.
Coutens B, Rekik K, Harster A, Etienne P, Noirot V, Frances B, Moulédous L, Guiard BP
Neuroscience (2020) : . 326 003 IHC; tested species: mouse
In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice.
Rodríguez-Matellán A, Alcazar N, Hernández F, Serrano M, Ávila J
Stem cell reports (2020) : . 326 003 IHC; tested species: mouse
Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice.
Mensching L, Djogo N, Keller C, Rading S, Karsak M
International journal of molecular sciences (2019) 2015: . 326 003 IHC; tested species: mouse
Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids.
Gabriel E, Ramani A, Karow U, Gottardo M, Natarajan K, Gooi LM, Goranci-Buzhala G, Krut O, Peters F, Nikolic M, Kuivanen S, et al.
Cell stem cell (2017) 203: 397-406.e5. 326 003 IHC; tested species: human
Cat. No.: 326 003
Quantity: 50 µg
Price: 370.00 €
A Citrus based sensory functional food ingredient induces antidepressant-like effects: possible involvement of an interplay between the olfactory and the serotonergic systems.
Coutens B, Rekik K, Harster A, Etienne P, Noirot V, Frances B, Moulédous L, Guiard BP
Neuroscience (2020) : . 326 003 IHC; tested species: mouse
In Vivo Reprogramming Ameliorates Aging Features in Dentate Gyrus Cells and Improves Memory in Mice.
Rodríguez-Matellán A, Alcazar N, Hernández F, Serrano M, Ávila J
Stem cell reports (2020) : . 326 003 IHC; tested species: mouse
Stable Adult Hippocampal Neurogenesis in Cannabinoid Receptor CB2 Deficient Mice.
Mensching L, Djogo N, Keller C, Rading S, Karsak M
International journal of molecular sciences (2019) 2015: . 326 003 IHC; tested species: mouse
Recent Zika Virus Isolates Induce Premature Differentiation of Neural Progenitors in Human Brain Organoids.
Gabriel E, Ramani A, Karow U, Gottardo M, Natarajan K, Gooi LM, Goranci-Buzhala G, Krut O, Peters F, Nikolic M, Kuivanen S, et al.
Cell stem cell (2017) 203: 397-406.e5. 326 003 IHC; tested species: human
Background
Doublecortin or DCX seems to be required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. Mutations in the gene encoding this protein have been linked to the double cortex syndrome.
Doublecortin is highly expressed in neuronal cells of fetal brain but absent from other tissues. In the adult dentate gyrus it is only expressed in cells contributing to adult neurogenesis.