GABABR2 antibody - 322 204 K.O.

GABABR2 is a metabotropic GABA receptor

Guinea pig polyclonal antiserum

Cat. No.: 322 204

Amount: 100 µl

Price: $365.00

Cat. No. 322 204	100 µl antiserum, lyophilized. For reconstitution add 100 µl H₂O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 1000 (AP staining) gallery IP: yes ICC: not tested yet IHC: not tested yet IHC-P: not tested yet Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section. Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section. Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section. Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section. Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.
Immunogen	Synthetic peptide corresponding to AA 917 to 940 from rat GABABR2 (UniProt Id: O88871)
Reactivity	Reacts with: rat (O88871), mouse (Q80T41). Other species not tested yet.
Specificity	K.O. validated
Data sheet	322_204.pdf

Cat. No.: 322 204

Amount: 100 µl

Price: $365.00

Background

Metabotropic g-aminobutyric acid type B receptors (GABABRs) are involved in the modulation of synaptic transmission and activity of cerebellar and thalamic neurons.
In contrast to the ionotrophic GABA-A receptors they are linked to G-proteins underlying the slow inhibitory postsynaptic potentials.
GABABR 1 and GABABR 2 have been shown to form heterodimers.

1 ) Kulik A et al., Eur. J. Neurosci. (2002)
2 ) Filippov AK et al., J. Neurosci. (2000)

Protocols

Standard protocol

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