Cat. No.: 314 004
Amount: 100 µl
Price:
350.00 €
Cat. No. 314 004 | 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use. |
Applications |
WB: 1 : 1000 (AP staining) gallery IP: yes ICC: 1 : 1000 gallery IHC: 1 : 200 gallery IHC-P/FFPE: 1 : 500 gallery |
Immunogen | Recombinant protein corresponding to AA 3 to 214 from mouse Tau-D (UniProt Id: P10637-5) |
Reactivity |
Reacts with: rat (P19332), mouse (P10637). Weaker signal: human (P10636). No signal: chicken. Other species not tested yet. |
Specificity | Specific for tau. Sequence used for immunization is present in all splice variants. |
Matching control protein/peptide | 314-0P |
Remarks |
The antibody binds phosphorylated and non-phosphorylated tau proteins. |
Data sheet | 314_004.pdf |
|
There are two major classes of heat stable microtubule associated proteins (MAPS): MAP 2 (280 kD), and tau (55-65 kD). Both protein classes are involved in the regulation of microtubule polymerization in cells. Tau is a neuronal protein that mainly localizes to axons. Hyperphosphorylated tau has been shown to be a major element of paired helical filaments in Alzheimer's disease.