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Home > Products > 314 004

Tau antibody - 314 004

Tau is a neuronal microtubule associated protein
Guinea pig polyclonal antiserum
Cat. No.: 314 004
Amount: 100 µl
Price: $365.00
Cat. No. 314 004 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 1000 gallery  
IHC: 1 : 200 gallery  
IHC-P: 1 : 500 gallery  
Immunogen Recombinant protein corresponding to the N-terminal half of mouse Tau-D (UniProt Id: P10637-5)
Reactivity Reacts with: rat (P19332), mouse (P10637).
Weaker signal: human (P10636).
No signal: chicken.
Other species not tested yet.
Specificity This antibody binds phosphorylated and non-phosphorylated tau proteins. The squence used for immunization is present in all splice variants except human TauA (UniProt Id: P10636-3)
Matching control protein/peptide 314-0P
Remarks

For human tissue cat.no. 314 012 and 314 111 are highly recommended.
Data sheet 314_004.pdf

References for Tau - 314 004

Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients.
Birnbaum JH, Wanner D, Gietl AF, Saake A, Kündig TM, Hock C, Nitsch RM, Tackenberg C
Stem cell research (2018) 27: 121-130. 314 004 WB; tested species: human
Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity.
Rosenberg EC, Chamberland S, Bazelot M, Nebet ER, Wang X, McKenzie S, Jain S, Greenhill S, Wilson M, Marley N, Salah A, et al.
Neuron (2023) : . 314 004 ICC; tested species: rat
Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation.
Pieger K, Schmitt V, Gauer C, Gießl N, Prots I, Winner B, Winkler J, Brandstätter JH, Xiang W
Biomolecules (2022) 128: . 314 004 ICC; tested species: human
Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice.
Hausrat TJ, Janiesch PC, Breiden P, Lutz D, Hoffmeister-Ullerich S, Hermans-Borgmeyer I, Failla AV, Kneussel M
Nature communications (2022) 131: 4192. 314 004 ICC; tested species: mouse
The ZIP3 zinc transporter is localized to mossy fiber terminals and is required for kainate-induced degeneration of CA3 neurons.
Bogdanovic M, Asraf H, Gottesman N, Sekler I, Aizenman E, Hershfinkel M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) : . 314 004 ICC; tested species: mouse
Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection.
Gunaseelan S, Ariffin MZ, Khanna S, Ooi MH, Perera D, Chu JJH, Chua JJE
Nature communications (2022) 131: 890. 314 004 ICC; tested species: rat
Guiding the Patterned Growth of Neuronal Axons and Dendrites Using Anisotropic Micropillar Scaffolds.
Fan S, Qi L, Li J, Pan D, Zhang Y, Li R, Zhang C, Wu D, Lau P, Hu Y, Bi G, et al.
Advanced healthcare materials (2021) 1012: e2100094. 314 004 ICC; tested species: rat
Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles.
Vilcaes AA, Chanaday NL, Kavalali ET
Neuron (2021) 1096: 971-983.e5. 314 004 ICC; tested species: mouse,rat
ZnT1 is a neuronal Zn2+/Ca2+ exchanger.
Gottesman N, Asraf H, Bogdanovic M, Sekler I, Tzounopoulos T, Aizenman E, Hershfinkel M
Cell calcium (2021) 101: 102505. 314 004 ICC; tested species: mouse
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5. 314 004 ICC; tested species: rat
Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size.
Salehi MS, Neumann ID, Jurek B, Pandamooz S
International journal of molecular sciences (2021) 2216: . 314 004 ICC; tested species: rat
A photoswitchable GPCR-based opsin for presynaptic inhibition.
Copits BA, Gowrishankar R, O'Neill PR, Li JN, Girven KS, Yoo JJ, Meshik X, Parker KE, Spangler SM, Elerding AJ, Brown BJ, et al.
Neuron (2021) 10911: 1791-1809.e11. 314 004 ICC; tested species: mouse
FEZ1 forms complexes with CRMP1 and DCC to regulate axon and dendrite development.
Chua JY, Ng SJ, Yagensky O, Wanker EE, Chua JJE
eNeuro (2021) : . 314 004 ICC; tested species: rat
Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.
Gunaseelan S, Wang Z, Tong VKJ, Ming SWS, Razar RBBA, Srimasorn S, Ong WY, Lim KL, Chua JJE
Human molecular genetics (2021) : . 314 004 ICC; tested species: human
Going Back and Forth: Episomal Vector Reprogramming of Peripheral Blood Mononuclear Cells to Induced Pluripotent Stem Cells and Subsequent Differentiation into Cardiomyocytes and Neuron-Astrocyte Co-cultures.
de Leeuw VC, van Oostrom CTM, Imholz S, Piersma AH, Hessel EVS, Dollé MET
Cellular reprogramming (2020) : . 314 004 ICC; tested species: human
Localisation of Formyl-Peptide Receptor 2 in the Rat Central Nervous System and Its Role in Axonal and Dendritic Outgrowth.
Ho CF, Ismail NB, Koh JK, Gunaseelan S, Low YH, Ng YK, Chua JJ, Ong WY
Neurochemical research (2018) 438: 1587-1598. 314 004 ICC; tested species: rat
Basal glucocorticoid receptor activation induces proliferation and inhibits neuronal differentiation of human induced pluripotent stem cell-derived neuronal precursor cells.
Nürnberg E, Horschitz S, Schloss P, Meyer-Lindenberg A
The Journal of steroid biochemistry and molecular biology (2018) : . 314 004 ICC; tested species: human
Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures.
Valtcheva MV, Copits BA, Davidson S, Sheahan TD, Pullen MY, McCall JG, Dikranian K, Gereau RW
Nature protocols (2016) 1110: 1877-88. 314 004 ICC
Impact of preconditioning with retinoic acid during early development on morphological and functional characteristics of human induced pluripotent stem cell-derived neurons.
Horschitz S, Matthäus F, Groß A, Rosner J, Galach M, Greffrath W, Treede RD, Utikal J, Schloss P, Meyer-Lindenberg A
Stem cell research (2015) 151: 30-41. 314 004 ICC
Herpes simplex virus membrane proteins gE/gI and US9 act cooperatively to promote transport of capsids and glycoproteins from neuron cell bodies into initial axon segments.
Howard PW, Howard TL, Johnson DC
Journal of virology (2013) 871: 403-14. 314 004 ICC
Phenotype and Stability of Neural Differentiation of Androgenetic Murine ES Cell-Derived Neural Progenitor Cells.
Wolber W, Ahmad R, Choi SW, Eckardt S, McLaughlin KJ, Schmitt J, Geis C, Heckmann M, Sirén AL, Müller AM
Cell medicine (2013) 51: 29-42. 314 004 ICC; tested species: mouse
Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells.
Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL, et al.
Molecular medicine (Cambridge, Mass.) (2013) 19: 399-408. 314 004 ICC; tested species: mouse
Nongenomic, glucocorticoid receptor-mediated regulation of serotonin transporter cell surface expression in embryonic stem cell derived serotonergic neurons.
Lau T, Heimann F, Bartsch D, Schloss P, Weber T
Neuroscience letters (2013) 554: 115-20. 314 004 ICC; tested species: mouse
Facilitation of neocortical presynaptic terminal development by NMDA receptor activation.
Sceniak MP, Berry CT, Sabo SL
Neural development (2012) 7: 8. 314 004 ICC
Human cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation.
Jabali A, Hoffrichter A, Uzquiano A, Marsoner F, Wilkens R, Siekmann M, Bohl B, Rossetti AC, Horschitz S, Koch P, Francis F, et al.
EMBO reports (2022) : e54027. 314 004 IHC; tested species: human
Differential roles of pyramidal and fast-spiking, GABAergic neurons in the control of glioma cell proliferation.
Tantillo E, Vannini E, Cerri C, Spalletti C, Colistra A, Mazzanti CM, Costa M, Caleo M
Neurobiology of disease (2020) 141: 104942. 314 004 IHC; tested species: mouse
Up-regulation of neurofilament light chains is associated with diminished immunoreactivities for MAP2 and tau after ischemic stroke in rodents and in a human case.
Härtig W, Krueger M, Hofmann S, Preißler H, Märkel M, Frydrychowicz C, Mueller WC, Bechmann I, Michalski D
Journal of chemical neuroanatomy (2016) 78: 140-148. 314 004 IHC
Cat. No.: 314 004
Amount: 100 µl
Price: $365.00
Oxidative stress and altered mitochondrial protein expression in the absence of amyloid-β and tau pathology in iPSC-derived neurons from sporadic Alzheimer's disease patients.
Birnbaum JH, Wanner D, Gietl AF, Saake A, Kündig TM, Hock C, Nitsch RM, Tackenberg C
Stem cell research (2018) 27: 121-130. 314 004 WB; tested species: human
Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity.
Rosenberg EC, Chamberland S, Bazelot M, Nebet ER, Wang X, McKenzie S, Jain S, Greenhill S, Wilson M, Marley N, Salah A, et al.
Neuron (2023) : . 314 004 ICC; tested species: rat
Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation.
Pieger K, Schmitt V, Gauer C, Gießl N, Prots I, Winner B, Winkler J, Brandstätter JH, Xiang W
Biomolecules (2022) 128: . 314 004 ICC; tested species: human
Disruption of tubulin-alpha4a polyglutamylation prevents aggregation of hyper-phosphorylated tau and microglia activation in mice.
Hausrat TJ, Janiesch PC, Breiden P, Lutz D, Hoffmeister-Ullerich S, Hermans-Borgmeyer I, Failla AV, Kneussel M
Nature communications (2022) 131: 4192. 314 004 ICC; tested species: mouse
The ZIP3 zinc transporter is localized to mossy fiber terminals and is required for kainate-induced degeneration of CA3 neurons.
Bogdanovic M, Asraf H, Gottesman N, Sekler I, Aizenman E, Hershfinkel M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2022) : . 314 004 ICC; tested species: mouse
Pharmacological perturbation of CXCL1 signaling alleviates neuropathogenesis in a model of HEVA71 infection.
Gunaseelan S, Ariffin MZ, Khanna S, Ooi MH, Perera D, Chu JJH, Chua JJE
Nature communications (2022) 131: 890. 314 004 ICC; tested species: rat
Guiding the Patterned Growth of Neuronal Axons and Dendrites Using Anisotropic Micropillar Scaffolds.
Fan S, Qi L, Li J, Pan D, Zhang Y, Li R, Zhang C, Wu D, Lau P, Hu Y, Bi G, et al.
Advanced healthcare materials (2021) 1012: e2100094. 314 004 ICC; tested species: rat
Interneuronal exchange and functional integration of synaptobrevin via extracellular vesicles.
Vilcaes AA, Chanaday NL, Kavalali ET
Neuron (2021) 1096: 971-983.e5. 314 004 ICC; tested species: mouse,rat
ZnT1 is a neuronal Zn2+/Ca2+ exchanger.
Gottesman N, Asraf H, Bogdanovic M, Sekler I, Tzounopoulos T, Aizenman E, Hershfinkel M
Cell calcium (2021) 101: 102505. 314 004 ICC; tested species: mouse
Presynaptic store-operated Ca2+ entry drives excitatory spontaneous neurotransmission and augments endoplasmic reticulum stress.
Chanaday NL, Nosyreva E, Shin OH, Zhang H, Aklan I, Atasoy D, Bezprozvanny I, Kavalali ET
Neuron (2021) 1098: 1314-1332.e5. 314 004 ICC; tested species: rat
Co-Stimulation of Oxytocin and Arginine-Vasopressin Receptors Affect Hypothalamic Neurospheroid Size.
Salehi MS, Neumann ID, Jurek B, Pandamooz S
International journal of molecular sciences (2021) 2216: . 314 004 ICC; tested species: rat
A photoswitchable GPCR-based opsin for presynaptic inhibition.
Copits BA, Gowrishankar R, O'Neill PR, Li JN, Girven KS, Yoo JJ, Meshik X, Parker KE, Spangler SM, Elerding AJ, Brown BJ, et al.
Neuron (2021) 10911: 1791-1809.e11. 314 004 ICC; tested species: mouse
FEZ1 forms complexes with CRMP1 and DCC to regulate axon and dendrite development.
Chua JY, Ng SJ, Yagensky O, Wanker EE, Chua JJE
eNeuro (2021) : . 314 004 ICC; tested species: rat
Loss of FEZ1, a gene deleted in Jacobsen syndrome, causes locomotion defects and early mortality by impairing motor neuron development.
Gunaseelan S, Wang Z, Tong VKJ, Ming SWS, Razar RBBA, Srimasorn S, Ong WY, Lim KL, Chua JJE
Human molecular genetics (2021) : . 314 004 ICC; tested species: human
Going Back and Forth: Episomal Vector Reprogramming of Peripheral Blood Mononuclear Cells to Induced Pluripotent Stem Cells and Subsequent Differentiation into Cardiomyocytes and Neuron-Astrocyte Co-cultures.
de Leeuw VC, van Oostrom CTM, Imholz S, Piersma AH, Hessel EVS, Dollé MET
Cellular reprogramming (2020) : . 314 004 ICC; tested species: human
Localisation of Formyl-Peptide Receptor 2 in the Rat Central Nervous System and Its Role in Axonal and Dendritic Outgrowth.
Ho CF, Ismail NB, Koh JK, Gunaseelan S, Low YH, Ng YK, Chua JJ, Ong WY
Neurochemical research (2018) 438: 1587-1598. 314 004 ICC; tested species: rat
Basal glucocorticoid receptor activation induces proliferation and inhibits neuronal differentiation of human induced pluripotent stem cell-derived neuronal precursor cells.
Nürnberg E, Horschitz S, Schloss P, Meyer-Lindenberg A
The Journal of steroid biochemistry and molecular biology (2018) : . 314 004 ICC; tested species: human
Surgical extraction of human dorsal root ganglia from organ donors and preparation of primary sensory neuron cultures.
Valtcheva MV, Copits BA, Davidson S, Sheahan TD, Pullen MY, McCall JG, Dikranian K, Gereau RW
Nature protocols (2016) 1110: 1877-88. 314 004 ICC
Impact of preconditioning with retinoic acid during early development on morphological and functional characteristics of human induced pluripotent stem cell-derived neurons.
Horschitz S, Matthäus F, Groß A, Rosner J, Galach M, Greffrath W, Treede RD, Utikal J, Schloss P, Meyer-Lindenberg A
Stem cell research (2015) 151: 30-41. 314 004 ICC
Herpes simplex virus membrane proteins gE/gI and US9 act cooperatively to promote transport of capsids and glycoproteins from neuron cell bodies into initial axon segments.
Howard PW, Howard TL, Johnson DC
Journal of virology (2013) 871: 403-14. 314 004 ICC
Phenotype and Stability of Neural Differentiation of Androgenetic Murine ES Cell-Derived Neural Progenitor Cells.
Wolber W, Ahmad R, Choi SW, Eckardt S, McLaughlin KJ, Schmitt J, Geis C, Heckmann M, Sirén AL, Müller AM
Cell medicine (2013) 51: 29-42. 314 004 ICC; tested species: mouse
Effects of erythropoietin in murine-induced pluripotent cell-derived panneural progenitor cells.
Offen N, Flemming J, Kamawal H, Ahmad R, Wolber W, Geis C, Zaehres H, Schöler HR, Ehrenreich H, Müller AM, Sirén AL, et al.
Molecular medicine (Cambridge, Mass.) (2013) 19: 399-408. 314 004 ICC; tested species: mouse
Nongenomic, glucocorticoid receptor-mediated regulation of serotonin transporter cell surface expression in embryonic stem cell derived serotonergic neurons.
Lau T, Heimann F, Bartsch D, Schloss P, Weber T
Neuroscience letters (2013) 554: 115-20. 314 004 ICC; tested species: mouse
Facilitation of neocortical presynaptic terminal development by NMDA receptor activation.
Sceniak MP, Berry CT, Sabo SL
Neural development (2012) 7: 8. 314 004 ICC
Human cerebral organoids reveal progenitor pathology in EML1-linked cortical malformation.
Jabali A, Hoffrichter A, Uzquiano A, Marsoner F, Wilkens R, Siekmann M, Bohl B, Rossetti AC, Horschitz S, Koch P, Francis F, et al.
EMBO reports (2022) : e54027. 314 004 IHC; tested species: human
Differential roles of pyramidal and fast-spiking, GABAergic neurons in the control of glioma cell proliferation.
Tantillo E, Vannini E, Cerri C, Spalletti C, Colistra A, Mazzanti CM, Costa M, Caleo M
Neurobiology of disease (2020) 141: 104942. 314 004 IHC; tested species: mouse
Up-regulation of neurofilament light chains is associated with diminished immunoreactivities for MAP2 and tau after ischemic stroke in rodents and in a human case.
Härtig W, Krueger M, Hofmann S, Preißler H, Märkel M, Frydrychowicz C, Mueller WC, Bechmann I, Michalski D
Journal of chemical neuroanatomy (2016) 78: 140-148. 314 004 IHC
WB
ICC
ICC
IHC
IHC-P
Background

There are two major classes of heat stable microtubule associated proteins (MAPS): MAP 2 (280 kD), and tau (55-65 kD). Both protein classes are involved in the regulation of microtubule polymerization in cells. Tau is a neuronal protein that mainly localizes to axons. Hyperphosphorylated tau has been shown to be a major element of paired helical filaments in Alzheimer's disease.
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