Cat. No.: 314 002
Amount: 200 µl
Price:
$355.00
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| Cat. No. 314 002 |
200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Immunogen | Recombinant protein corresponding to the N-terminal half of mouse Tau-D (UniProt Id: P10637-5) |
| Reactivity |
Reacts with: rat (P19332), mouse (P10637). Weaker signal: human (P10636). Other species not tested yet. |
| Specificity | This antibody binds phosphorylated and non-phosphorylated tau proteins. The sequence used for immunization is present in all splice variants except human TauA (UniProt Id: P10636-3). |
| Matching control protein/peptide | 314-0P |
| Remarks |
For human tissue cat.no. 314 012 and 314 111 are highly recommended. |
| Data sheet | 314_002.pdf |
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There are two major classes of heat stable microtubule associated proteins (MAPS): MAP 2 (280 kD), and tau (55-65 kD). Both protein classes are involved in the regulation of microtubule polymerization in cells. Tau is a neuronal protein that mainly localizes to axons. Hyperphosphorylated tau has been shown to be a major element of paired helical filaments in Alzheimer's disease.