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Tau - 314 002

A microtubule associated protein
Polyclonal rabbit antiserum
Cat. No.: 314 002
Amount: 200 µl
Price: $350.00
Cat. No. 314 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) gallery  
IP: yes
ICC: 1 : 1000 gallery  
IHC: yes gallery  
IHC-P/FFPE: not tested yet
Immunogen Recombinant protein corresponding to AA 3 to 214 from mouse Tau-D (UniProt Id: P10637-5)
Reactivity Reacts with: rat (P19332), mouse (P10637).
Weaker signal: human (P10636).
Other species not tested yet.
Specificity Specific for tau. Sequence used for immunization is present in all splice variants.
Matching control protein/peptide 314-0P
Remarks

The antibody binds phosphorylated and non-phosphorylated tau proteins.For human tissue antibody 2, cat.no. 314 012, is highly recommended.

Data sheet 314_002.pdf

References for Tau - 314 002

The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner.
Gauthier-Kemper A, Weissmann C, Golovyashkina N, Sebö-Lemke Z, Drewes G, Gerke V, Heinisch JJ, Brandt R
The Journal of cell biology (2011) 1924: 647-61. 314 002 WB, ICC
The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons.
Tonazzini I, Van Woerden GM, Masciullo C, Mientjes EJ, Elgersma Y, Cecchini M
Molecular autism (2019) 10: 41. 314 002 ICC; tested species: mouse
Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones.
Vysokov NV, Silva JP, Lelianova VG, Suckling J, Cassidy J, Blackburn JK, Yankova N, Djamgoz MB, Kozlov SV, Tonevitsky AG, Ushkaryov YA, et al.
eLife (2018) 7: . 314 002 ICC; tested species: rat
HuD Is a Neural Translation Enhancer Acting on mTORC1-Responsive Genes and Counteracted by the Y3 Small Non-coding RNA.
Tebaldi T, Zuccotti P, Peroni D, Köhn M, Gasperini L, Potrich V, Bonazza V, Dudnakova T, Rossi A, Sanguinetti G, Conti L, et al.
Molecular cell (2018) 712: 256-270.e10. 314 002 ICC; tested species: mouse
Biocompatibility of a Magnetic Tunnel Junction Sensor Array for the Detection of Neuronal Signals in Culture.
Moretti D, DiFrancesco ML, Sharma PP, Dante S, Albisetti E, Monticelli M, Bertacco R, Petti D, Baldelli P, Benfenati F
Frontiers in neuroscience (2018) 12: 909. 314 002 ICC; tested species: rat
CRMP1 and CRMP2 have synergistic but distinct roles in dendritic development.
Makihara H, Nakai S, Ohkubo W, Yamashita N, Nakamura F, Kiyonari H, Shioi G, Jitsuki-Takahashi A, Nakamura H, Tanaka F, Akase T, et al.
Genes to cells : devoted to molecular & cellular mechanisms (2016) 219: 994-1005. 314 002 ICC; tested species: mouse
The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner.
Gauthier-Kemper A, Weissmann C, Golovyashkina N, Sebö-Lemke Z, Drewes G, Gerke V, Heinisch JJ, Brandt R
The Journal of cell biology (2011) 1924: 647-61. 314 002 WB, ICC
Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves.
Abe N, Borson SH, Gambello MJ, Wang F, Cavalli V
The Journal of biological chemistry (2010) 28536: 28034-43. 314 002 ICC
Cat. No.: 314 002
Quantity: 200 µl
Price: $350.00
The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner.
Gauthier-Kemper A, Weissmann C, Golovyashkina N, Sebö-Lemke Z, Drewes G, Gerke V, Heinisch JJ, Brandt R
The Journal of cell biology (2011) 1924: 647-61. 314 002 WB, ICC
The role of ubiquitin ligase E3A in polarized contact guidance and rescue strategies in UBE3A-deficient hippocampal neurons.
Tonazzini I, Van Woerden GM, Masciullo C, Mientjes EJ, Elgersma Y, Cecchini M
Molecular autism (2019) 10: 41. 314 002 ICC; tested species: mouse
Proteolytically released Lasso/teneurin-2 induces axonal attraction by interacting with latrophilin-1 on axonal growth cones.
Vysokov NV, Silva JP, Lelianova VG, Suckling J, Cassidy J, Blackburn JK, Yankova N, Djamgoz MB, Kozlov SV, Tonevitsky AG, Ushkaryov YA, et al.
eLife (2018) 7: . 314 002 ICC; tested species: rat
HuD Is a Neural Translation Enhancer Acting on mTORC1-Responsive Genes and Counteracted by the Y3 Small Non-coding RNA.
Tebaldi T, Zuccotti P, Peroni D, Köhn M, Gasperini L, Potrich V, Bonazza V, Dudnakova T, Rossi A, Sanguinetti G, Conti L, et al.
Molecular cell (2018) 712: 256-270.e10. 314 002 ICC; tested species: mouse
Biocompatibility of a Magnetic Tunnel Junction Sensor Array for the Detection of Neuronal Signals in Culture.
Moretti D, DiFrancesco ML, Sharma PP, Dante S, Albisetti E, Monticelli M, Bertacco R, Petti D, Baldelli P, Benfenati F
Frontiers in neuroscience (2018) 12: 909. 314 002 ICC; tested species: rat
CRMP1 and CRMP2 have synergistic but distinct roles in dendritic development.
Makihara H, Nakai S, Ohkubo W, Yamashita N, Nakamura F, Kiyonari H, Shioi G, Jitsuki-Takahashi A, Nakamura H, Tanaka F, Akase T, et al.
Genes to cells : devoted to molecular & cellular mechanisms (2016) 219: 994-1005. 314 002 ICC; tested species: mouse
The frontotemporal dementia mutation R406W blocks tau's interaction with the membrane in an annexin A2-dependent manner.
Gauthier-Kemper A, Weissmann C, Golovyashkina N, Sebö-Lemke Z, Drewes G, Gerke V, Heinisch JJ, Brandt R
The Journal of cell biology (2011) 1924: 647-61. 314 002 WB, ICC
Mammalian target of rapamycin (mTOR) activation increases axonal growth capacity of injured peripheral nerves.
Abe N, Borson SH, Gambello MJ, Wang F, Cavalli V
The Journal of biological chemistry (2010) 28536: 28034-43. 314 002 ICC
Background

There are two major classes of heat stable microtubule associated proteins (MAPS): MAP 2 (280 kD), and tau (55-65 kD). Both protein classes are involved in the regulation of microtubule polymerization in cells. Tau is a neuronal protein that mainly localizes to axons. Hyperphosphorylated tau has been shown to be a major element of paired helical filaments in Alzheimer's disease.