Cat. No.: 312 011
Amount: 100 µg
Price:
$415.00
|
|
|
| Cat. No. 312 011 |
100 µg purified IgG, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | JP63 |
| Subtype | IgG1 (κ light chain) |
| Immunogen | Recombinant protein corresponding to AA 1 to 1618 from human Nestin (UniProt Id: P48681) |
| Reactivity |
Reacts with: human (P48681). Other species not tested yet. |
| Data sheet | 312_011.pdf |
|
|
Nestin is a type VI intermediate filament and is expressed in early embryonic neuroepithelial stem cells during CNS development (1). The protein is downregulated and replaced by other tissue specific intermediate filaments during differentiation (2). Antibodies against Nestin can be employed as predominant markers for stem and progenitor cells in the mammalian CNS.
During neuroinflammation and ischemia, Nestin is upregulated in different CNS cell types (2).
Expression has also been reported for proliferative endothelial cells of various tissues like newly formed blood vessels in brain (3), glomeruli of kidney (4) and skin (5). Moreover, Nestin has garnered significant attention in oncology, as its re-expression is associated with various cancers, including glioblastomas and melanomas (6).