|Cat. No. 308 111||100 µg purified IgG, lyophilized. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.|
WB: 1 : 500 up to 1 : 10000
IHC: not tested yet
IHC-P/FFPE: not tested yet
|Subtype||IgG2a (κ light chain)|
|Immunogen||Recombinant protein corresponding to AA 1 to 140 from bovine Profilin1 (UniProt Id: P02584)|
Epitop: AA 42 to 47 from bovine Profilin1 (UniProt Id: P02584)
|Specificity||Specific for birch profilin.|
This antibody has been used successfully with eucaryotic and procaryotic expression vectors using the epitope as a tag (Rudiger et al. 1997).
Profilins are small proteins (14-17 kDa) which are involved in the regulation of the cellular microfilament system. They are associated with highly dynamic microfilament structures present at cellular membranes. Profilins have been found together with lamellipodia, focal adhesions, surface ruffles and on intracellular vesicles and have been shown to interact with different cytoskeleton proteins like actin, gephyrin and the Arp 2/3 complex. Recently a tumor suppression activity has been described for profilin.