Synaptic Systems

Cat. No.: 305 011

Amount: 100 µg

Price: $420.00

Cat. No. 305 011	100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 100 up to 1 : 2000 (AP staining) gallery IP: not tested yet ICC: yes IHC: not tested yet IHC-P: not tested yet
Clone	323H3
Subtype	IgG2a (κ light chain)
Immunogen	Recombinant protein corresponding to AA 1 to 151 from human p16-Arc (UniProt Id: O15511)
Epitop	AA 19 to 24 from human p16-Arc (UniProt Id: O15511)
Reactivity	Reacts with: human (O15511), rat (Q4KLF8), mouse (Q9CPW4), hamster. Other species not tested yet.
Specificity	K.O. validated PubMed: 37349293
Data sheet	305_011.pdf

References for p16-Arc - 305 011

Inherited ARPC5 mutations cause an actinopathy impairing cell motility and disrupting cytokine signaling.
Nunes-Santos CJ, Kuehn H, Boast B, Hwang S, Kuhns DB, Stoddard J, Niemela JE, Fink DL, Pittaluga S, Abu-Asab M, Davies JS, et al.
Nature communications (2023) 141: 3708. 305 011 WB; KO verified; tested species: human

ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells.
Sadhu L, Tsopoulidis N, Hasanuzzaman M, Laketa V, Way M, Fackler OT
eLife (2023) 12: . 305 011 WB; KD verified; tested species: mouse

MICAL2 enhances branched actin network disassembly by oxidizing Arp3B-containing Arp2/3 complexes.
Galloni C, Carra D, Abella JVG, Kjær S, Singaravelu P, Barry DJ, Kogata N, Guérin C, Blanchoin L, Way M
The Journal of cell biology (2021) 2208: . 305 011 WB; tested species: human

The Arp1/11 minifilament of dynactin primes the endosomal Arp2/3 complex.
Fokin AI, David V, Oguievetskaia K, Derivery E, Stone CE, Cao L, Rocques N, Molinie N, Henriot V, Aumont-Nicaise M, Hinckelmann MV, et al.
Science advances (2021) 73: . 305 011 WB; tested species: mouse

Loss of MAGEL2 in Prader-Willi syndrome leads to decreased secretory granule and neuropeptide production.
Chen H, Victor AK, Klein J, Tacer KF, Tai DJ, de Esch C, Nuttle A, Temirov J, Burnett LC, Rosenbaum M, Zhang Y, et al.
JCI insight (2020) 517: . 305 011 WB; tested species: human

Ezrin promotes actin assembly at the phagosome membrane and regulates phago-lysosomal fusion.
Marion S, Hoffmann E, Holzer D, Le Clainche C, Martin M, Sachse M, Ganeva I, Mangeat P, Griffiths G
Traffic (Copenhagen, Denmark) (2011) 124: 421-37. 305 011 WB; tested species: mouse

Molecular anatomy of a trafficking organelle.
Takamori S, Holt M, Stenius K, Lemke EA, Grønborg M, Riedel D, Urlaub H, Schenck S, Brügger B, Ringler P, Müller SA, et al.
Cell (2006) 1274: 831-46. 305 011 WB

Filopodia formation in the absence of functional WAVE- and Arp2/3-complexes.
Steffen A, Faix J, Resch GP, Linkner J, Wehland J, Small JV, Rottner K, Stradal TE
Molecular biology of the cell (2006) 176: 2581-91. 305 011 WB

Cat. No.: 305 011

Amount: 100 µg

Price: $420.00

Background

Protocols

p16-Arc antibody - 305 011 K.O.

References for p16-Arc - 305 011