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S100B antibody - 287 006

S100B is a marker for mature astrocytes
Chicken polyclonal purified antibody
Cat. No.: 287 006
Amount: 50 µg
Price: $370.00
Cat. No. 287 006 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications
 
WB: not recommended
IP: not tested yet
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 up to 1 : 1000      gallery  
Immunogen Recombinant protein corresponding to AA 1 to 92 from rat S100B (UniProt Id: P04631)
Reactivity Reacts with: rat (P04631), mouse (P50114), human (P04271).
Other species not tested yet.
Specificity Specific for S100B
Data sheet 287_006.pdf

References for S100B - 287 006

Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.
Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, et al.
Cell metabolism (2018) : . 287 006 ICC; tested species: mouse
Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis.
Wilke JBH, Hindermann M, Berghoff SA, Zihsler S, Arinrad S, Ronnenberg A, Barnkothe N, Steixner-Kumar AA, Röglin S, Stöcker W, Hollmann M, et al.
Molecular psychiatry (2021) : . 287 006 IHC; tested species: mouse
Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain.
Venturino A, Schulz R, De Jesús-Cortés H, Maes ME, Nagy B, Reilly-Andújar F, Colombo G, Cubero RJA, Schoot Uiterkamp FE, Bear MF, Siegert S, et al.
Cell reports (2021) 361: 109313. 287 006 IHC; tested species: mouse
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.
Konishi H, Okamoto T, Hara Y, Komine O, Tamada H, Maeda M, Osako F, Kobayashi M, Nishiyama A, Kataoka Y, Takai T, et al.
The EMBO journal (2020) 3922: e104464. 287 006 IHC; tested species: mouse
SRF Is Required for Maintenance of Astrocytes in Non-Reactive State in the Mammalian Brain.
Jain M, Das S, Lu PPY, Virmani G, Soman S, Thumu SCR, Gutmann DH, Ramanan N
eNeuro () 81: . 287 006 IHC; tested species: mouse
Astrocytes expressing Vitamin D-activating enzyme identify Parkinson's disease.
Mazzetti S, Barichella M, Giampietro F, Giana A, Calogero AM, Amadeo A, Palazzi N, Comincini A, Giaccone G, Bramerio M, Caronni S, et al.
CNS neuroscience & therapeutics (2022) : . 287 006 IHC-P; tested species: human
Cat. No.: 287 006
Amount: 50 µg
Price: $370.00
Obesity-Induced Cellular Senescence Drives Anxiety and Impairs Neurogenesis.
Ogrodnik M, Zhu Y, Langhi LGP, Tchkonia T, Krüger P, Fielder E, Victorelli S, Ruswhandi RA, Giorgadze N, Pirtskhalava T, Podgorni O, et al.
Cell metabolism (2018) : . 287 006 ICC; tested species: mouse
Autoantibodies against NMDA receptor 1 modify rather than cause encephalitis.
Wilke JBH, Hindermann M, Berghoff SA, Zihsler S, Arinrad S, Ronnenberg A, Barnkothe N, Steixner-Kumar AA, Röglin S, Stöcker W, Hollmann M, et al.
Molecular psychiatry (2021) : . 287 006 IHC; tested species: mouse
Microglia enable mature perineuronal nets disassembly upon anesthetic ketamine exposure or 60-Hz light entrainment in the healthy brain.
Venturino A, Schulz R, De Jesús-Cortés H, Maes ME, Nagy B, Reilly-Andújar F, Colombo G, Cubero RJA, Schoot Uiterkamp FE, Bear MF, Siegert S, et al.
Cell reports (2021) 361: 109313. 287 006 IHC; tested species: mouse
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.
Konishi H, Okamoto T, Hara Y, Komine O, Tamada H, Maeda M, Osako F, Kobayashi M, Nishiyama A, Kataoka Y, Takai T, et al.
The EMBO journal (2020) 3922: e104464. 287 006 IHC; tested species: mouse
SRF Is Required for Maintenance of Astrocytes in Non-Reactive State in the Mammalian Brain.
Jain M, Das S, Lu PPY, Virmani G, Soman S, Thumu SCR, Gutmann DH, Ramanan N
eNeuro () 81: . 287 006 IHC; tested species: mouse
Astrocytes expressing Vitamin D-activating enzyme identify Parkinson's disease.
Mazzetti S, Barichella M, Giampietro F, Giana A, Calogero AM, Amadeo A, Palazzi N, Comincini A, Giaccone G, Bramerio M, Caronni S, et al.
CNS neuroscience & therapeutics (2022) : . 287 006 IHC-P; tested species: human
Background

The family of S100 proteins comprises more than 20 members. These proteins are EF-hand Ca2+-binding proteins, and are widely distributed in mammalian tissue. Since these proteins are soluble in 100 % saturated ammonium-sulfate solution they have been named S100.
S100B is a frequently used marker protein for mature astrocytes whereas GFAP is also expressed in germinal zone cells that maintained their immature developmental stage.