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CAPS2 antibody - 262 103 K.O.

CAPS2 is a Ca2+-dependent secretion activator
Rabbit polyclonal purified antibody
Cat. No.: 262 103
Amount: 50 µg
Price: $375.00
Cat. No. 262 103 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 500 up to 1 : 1000 gallery  
IP: not tested yet
ICC: not tested yet
IHC: yes
IHC-P: not tested yet
Immunogen Recombinant protein corresponding to AA 15 to 89 from mouse CAPS2 (UniProt Id: Q8BYR5)
Reactivity Reacts with: mouse (Q8BYR5).
Other species not tested yet.
Specificity Specific for CAPS 2, no cross-reactvity to CAPS 1 K.O. validated
Data sheet 262_103.pdf

References for CAPS2 - 262 103

Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2.
Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, et al.
eLife (2020) 9: . 262 103 WB; tested species: rat
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.
Vogl C, Cooper BH, Neef J, Wojcik SM, Reim K, Reisinger E, Brose N, Rhee JS, Moser T, Wichmann C
Journal of cell science (2015) 1284: 638-44. 262 103 IHC
Cat. No.: 262 103
Amount: 50 µg
Price: $375.00
Distinct insulin granule subpopulations implicated in the secretory pathology of diabetes types 1 and 2.
Kreutzberger AJB, Kiessling V, Doyle CA, Schenk N, Upchurch CM, Elmer-Dixon M, Ward AE, Preobraschenski J, Hussein SS, Tomaka W, Seelheim P, et al.
eLife (2020) 9: . 262 103 WB; tested species: rat
Unconventional molecular regulation of synaptic vesicle replenishment in cochlear inner hair cells.
Vogl C, Cooper BH, Neef J, Wojcik SM, Reim K, Reisinger E, Brose N, Rhee JS, Moser T, Wichmann C
Journal of cell science (2015) 1284: 638-44. 262 103 IHC
Background
The Ca2+-dependent activator protein for secretion (CAPS) regulates exocytosis of catecholamine- or neuropeptide-containing dense-core vesicles (DCVs) at secretion sites.
Two differen isoforms CAPS 1/CADPS 1 and CAPS 2/CADPS 2 that are mainly expressed in brain have been identified in mammals. Both have been shown to be essential components of the synaptic vesicle priming machinery.