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Home > Products > 258 104

Cannabinoid receptor CB1-R antibody - 258 104

CB1-R is a G-protein coupled receptor responsive to cannabinoids
Guinea pig polyclonal antiserum
Cat. No.: 258 104
Amount: 100 µl
Price: $365.00
Cat. No. 258 104 100 µl antiserum, lyophilized. For reconstitution add 100 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: not recommended
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P: 1 : 500 gallery  

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.
Immunogen Synthetic peptide corresponding to AA 450 to 473 from rat CB1-R (UniProt Id: P20272)
Reactivity Reacts with: rat (P20272), mouse (P47746).
Other species not tested yet.
Data sheet 258_104.pdf

References for Cannabinoid receptor CB1-R - 258 104

The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.
Wen L, Yang X, Wu Z, Fu S, Zhan Y, Chen Z, Bi D, Shen Y
Cell reports (2023) 424: 112349. 258 104 IHC; tested species: mouse
Neuronal Dystroglycan regulates postnatal development of CCK/cannabinoid receptor-1 interneurons.
Miller DS, Wright KM
Neural development (2021) 161: 4. 258 104 IHC; tested species: mouse
Cat. No.: 258 104
Amount: 100 µl
Price: $365.00
The complement inhibitor CD59 is required for GABAergic synaptic transmission in the dentate gyrus.
Wen L, Yang X, Wu Z, Fu S, Zhan Y, Chen Z, Bi D, Shen Y
Cell reports (2023) 424: 112349. 258 104 IHC; tested species: mouse
Neuronal Dystroglycan regulates postnatal development of CCK/cannabinoid receptor-1 interneurons.
Miller DS, Wright KM
Neural development (2021) 161: 4. 258 104 IHC; tested species: mouse
ICC
IHC
IHC-P
Background
The cannabinoid receptor CB1-R is a G-protein coupled receptor (GPCR) with 7 transmembrane domains. It is responsive to tetrahydrocannabinol, the psychotropic component of marijuana.
Endogenous cannabinoids (endocannabinoids) are released from postsynaptic neurons and act onto presynaptic cannabinoid receptors where they play important physiological roles in synaptic plasticity, analgesia, appetite, and neuroprotection.
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