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Cannabinoid receptor CB1-R antibody - 258 011

CB1-R is a G-protein coupled receptor responsive to cannabinoids
Monoclonal mouse purified IgG
Cat. No.: 258 011
Amount: 100 µg
Price: $415.00
Cat. No. 258 011 100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: 1 : 500 gallery  
Clone 289C1
Subtype IgG2b (κ light chain)
Immunogen Synthetic peptide corresponding to AA 450 to 473 from rat CB1-R (UniProt Id: P20272)
Reactivity Reacts with: rat (P20272), mouse (P47746), human (P21554).
Other species not tested yet.
Specificity Specific for CB1-R. K.O.
Data sheet 258_011.pdf

References for Cannabinoid receptor CB1-R - 258 011

A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 258 011 IHC; tested species: rat
Early-life stress exacerbates the effects of WIN55,212-2 and modulates the cannabinoid receptor type 1 expression.
Martín-Sánchez A, García-Baos A, Castro-Zavala A, Alegre-Zurano L, Valverde O
Neuropharmacology (2020) : 108416. 258 011 IHC; tested species: mouse
Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
Hu HY, Kruijssen DLH, Frias CP, Rózsa B, Hoogenraad CC, Wierenga CJ
Cell reports (2019) 273: 666-675.e5. 258 011 IHC; tested species: mouse
The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra.
Davis MI, Crittenden JR, Feng AY, Kupferschmidt DA, Naydenov A, Stella N, Graybiel AM, Lovinger DM
PloS one (2018) 132: e0191436. 258 011 IHC; tested species: mouse
Cat. No.: 258 011
Quantity: 100 µg
Price: $415.00
A High-Resolution Method for Quantitative Molecular Analysis of Functionally Characterized Individual Synapses.
Holderith N, Heredi J, Kis V, Nusser Z
Cell reports (2020) 324: 107968. 258 011 IHC; tested species: rat
Early-life stress exacerbates the effects of WIN55,212-2 and modulates the cannabinoid receptor type 1 expression.
Martín-Sánchez A, García-Baos A, Castro-Zavala A, Alegre-Zurano L, Valverde O
Neuropharmacology (2020) : 108416. 258 011 IHC; tested species: mouse
Endocannabinoid Signaling Mediates Local Dendritic Coordination between Excitatory and Inhibitory Synapses.
Hu HY, Kruijssen DLH, Frias CP, Rózsa B, Hoogenraad CC, Wierenga CJ
Cell reports (2019) 273: 666-675.e5. 258 011 IHC; tested species: mouse
The cannabinoid-1 receptor is abundantly expressed in striatal striosomes and striosome-dendron bouquets of the substantia nigra.
Davis MI, Crittenden JR, Feng AY, Kupferschmidt DA, Naydenov A, Stella N, Graybiel AM, Lovinger DM
PloS one (2018) 132: e0191436. 258 011 IHC; tested species: mouse
Background
The cannabinoid receptor CB1-R is a G-protein coupled receptor (GPCR) with 7 transmembrane domains. It is responsive to tetrahydrocannabinol, the psychotropic component of marijuana.
Endogenous cannabinoids (endocannabinoids) are released from postsynaptic neurons and act onto presynaptic cannabinoid receptors where they play important physiological roles in synaptic plasticity, analgesia, appetite, and neuroprotection.