Home|||||||Technical Support|

EEA 1 antibody - 237 105

EEA1 is an endosomal Rab 5 effector essential for endocytic membrane fusion
Polyclonal Guinea pig purified antibody
Cat. No.: 237 105
Amount: 50 µg
Price: $450.00
Cat. No. 237 105 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 AP staining gallery  
IP: not tested yet
ICC: 1 : 500 gallery  
IHC: 1 : 500 gallery  
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 1 to 15 from mouse EEA1 (UniProt Id: Q8BL66)
Reactivity Reacts with: mouse (Q8BL66), rat (A0A0G2K051).
Other species not tested yet.
Specificity Specific for EEA 1
Data sheet 237_105.pdf

References for EEA 1 - 237 105

The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression.
Wu D, Wang S, Oliveira DV, Del Gaudio F, Vanlandewijck M, Lebouvier T, Betsholtz C, Zhao J, Jin S, Lendahl U, Karlström H, et al.
Disease models & mechanisms (2021) : . 237 105 ICC; tested species: human
Cat. No.: 237 105
Quantity: 50 µg
Price: $450.00
The infantile myofibromatosis NOTCH3 L1519P mutation leads to hyperactivated ligand-independent Notch signaling and increased PDGFRB expression.
Wu D, Wang S, Oliveira DV, Del Gaudio F, Vanlandewijck M, Lebouvier T, Betsholtz C, Zhao J, Jin S, Lendahl U, Karlström H, et al.
Disease models & mechanisms (2021) : . 237 105 ICC; tested species: human
Background
Extracellular compounds are internalized by endocytosis into so called endocytic vesicles. They fuse with early endosomes, from where the endocytosed material can be shuttled to a number of alternative destinations.
Early endosomal antigen 1 (EEA 1) is a peripheral membrane protein that locates to early endosomes via binding to the membrane lipid phosphatidylinositol 3-phosphate (PtdIns3P) and the active form of Rab5.
Autoantibodies against EEA 1 have been shown to be associated with subacute cutaneous systemic lupus erythematosus.