Home|||||||Technical Support|

GABA-A receptor alpha6 - 224 603

Receptors mediating inhibitory neurotransmission
Polyclonal rabbit purified antibody
Cat. No.: 224 603
Amount: 50 µg
Price: 370.00 €
Cat. No. 224 603 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: 1 : 1000 (AP staining) (see remarks) gallery  
IP: not tested yet
ICC: not tested yet
IHC: 1 : 500 gallery  
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 20 to 30 from rat GABA-A receptor α6 (UniProt Id: P30191)
Reactivity Reacts with: rat (P30191), mouse (P16305).
Other species not tested yet.
Specificity Specific for GABA-A receptor α6.
Remarks

WB:  GABA-A receptor alpha6 aggregates after boiling, making it necessary to run SDS-PAGE with non-boiled samples.

Data sheet 224_603.pdf

References for GABA-A receptor alpha6 - 224 603

Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation.
Joensuu T, Tegelberg S, Reinmaa E, Segerstråle M, Hakala P, Pehkonen H, Korpi ER, Tyynelä J, Taira T, Hovatta I, Kopra O, et al.
PloS one (2014) 92: e89321. 224 603 WB, IHC
Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation.
Joensuu T, Tegelberg S, Reinmaa E, Segerstråle M, Hakala P, Pehkonen H, Korpi ER, Tyynelä J, Taira T, Hovatta I, Kopra O, et al.
PloS one (2014) 92: e89321. 224 603 WB, IHC
Cat. No.: 224 603
Quantity: 50 µg
Price: 370.00 €
Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation.
Joensuu T, Tegelberg S, Reinmaa E, Segerstråle M, Hakala P, Pehkonen H, Korpi ER, Tyynelä J, Taira T, Hovatta I, Kopra O, et al.
PloS one (2014) 92: e89321. 224 603 WB, IHC
Gene expression alterations in the cerebellum and granule neurons of Cstb(-/-) mouse are associated with early synaptic changes and inflammation.
Joensuu T, Tegelberg S, Reinmaa E, Segerstråle M, Hakala P, Pehkonen H, Korpi ER, Tyynelä J, Taira T, Hovatta I, Kopra O, et al.
PloS one (2014) 92: e89321. 224 603 WB, IHC
Background

Gamma-aminobutyric acid type A (GABA-A) receptors mediate the majority of inhibitory neurotransmission in the brain. These receptor proteins are ligand gated chloride ion channels and consist of a pentameric combination of different subunits (alpha, beta, gamma, delta, epsilon and rho). The resulting heterogenous population of GABA-A receptor subtypes are expressed throughout the brain with specific cellular and subcellular expression patterns.