Synaptic Systems - GABA-A receptor gamma2

Cat. No.: 224 003

Amount: 50 µg

Price: $400.00

Cat. No. 224 003	50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 1000 (AP staining) (see remarks) gallery IP: yes ICC: 1 : 500 (see remarks) gallery IHC: 1 : 1000 (see remarks) gallery IHC-P: not tested yet EM: yes Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section. Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section. Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section. Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section. Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Electron microscopy (EM) is a microscopy technique that detects the scatter of electrons through thin tissue sections. In Immuno-EM the antigen is usually revealed by colloidal gold conjugated secondary antibodies linking electron dense structures to antigen-bound primary antibodies.
Immunogen	Synthetic peptide corresponding to AA 39 to 67 from mouse GABA-A receptor γ2 (UniProt Id: P22723)
Reactivity	Reacts with: human (P18507), rat (P18508), mouse (P22723), monkey, zebrafish. Other species not tested yet.
Specificity	Specific for GABA-A receptor γ2. Does not discriminate between the L and S form. K.O. validated PubMed: 24849349
Matching control protein/peptide	224-0P
Remarks	WB: GABA-A receptor gamma2 aggregates after boiling, making it necessary to run SDS-PAGE with non-boiled samples. ICC: This antibody is also suitable for the surface staining of living cells. After washing cells with bound antibodies, they can be fixed and visualized with secondary reagents. IHC: For best results use the protocol of Schneider Gasser et al., 2006. Glyoxal fixation according to Konno et al. 2023 has improved signal quality and strength.
Data sheet	224_003.pdf

References for GABA-A receptor gamma2 - 224 003

Activity in the dorsal hippocampus-mPFC circuit modulates stress-coping strategies during inescapable stress.
Yoon SH, Song WS, Chung G, Kim SJ, Kim MH
Experimental & molecular medicine (2024) : . 224 003 WB; tested species: mouse

Photoproximity labeling of endogenous receptors in the live mouse brain in minutes.
Takato M, Sakamoto S, Nonaka H, Tanimura Valor FY, Tamura T, Hamachi I
Nature chemical biology (2024) : . 224 003 WB; tested species: mouse

Wheel-Running Exercise Alleviates Anxiety-Like Behavior via Down-Regulating S-Nitrosylation of Gephyrin in the Basolateral Amygdala of Male Rats.
Yang PF, Nie TL, Sun XN, Xu LX, Ma C, Wang F, Long LH, Chen JG
Advanced science (Weinheim, Baden-Wurttemberg, Germany) (2024) : e2400205. 224 003 WB; tested species: rat

Inhibitory and excitatory synaptic neuroadaptations in the diazepam tolerant brain.
Lorenz-Guertin JM, Povysheva N, Chapman CA, MacDonald ML, Fazzari M, Nigam A, Nuwer JL, Das S, Brady ML, Vajn K, Bambino MJ, et al.
Neurobiology of disease (2023) : 106248. 224 003 WB, IP; tested species: mouse

Altered expression of synaptic proteins and adhesion molecules in the hippocampus and cortex following the onset of diabetes in nonobese diabetic mice.
Yokokawa T, Kido K, Sato K, Hayashi T, Fujita S
Physiological reports (2023) 118: e15673. 224 003 WB; tested species: mouse

Kv7/KCNQ potassium channels in cortical hyperexcitability and juvenile seizure-related death in Ank2-mutant mice.
Oh H, Lee S, Oh Y, Kim S, Kim YS, Yang Y, Choi W, Yoo YE, Cho H, Lee S, Yang E, et al.
Nature communications (2023) 141: 3547. 224 003 WB; tested species: mouse

Cannabidiol modulates excitatory-inhibitory ratio to counter hippocampal hyperactivity.
Rosenberg EC, Chamberland S, Bazelot M, Nebet ER, Wang X, McKenzie S, Jain S, Greenhill S, Wilson M, Marley N, Salah A, et al.
Neuron (2023) : . 224 003 WB, ICC; tested species: rat

The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors.
Whittsette AL, Wang YJ, Mu TW
iScience (2022) 258: 104754. 224 003 WB, UPTAKE; tested species: rat

REST/NRSF drives homeostatic plasticity of inhibitory synapses in a target-dependent fashion.
Prestigio C, Ferrante D, Marte A, Romei A, Lignani G, Onofri F, Valente P, Benfenati F, Baldelli P
eLife (2021) 10: . 224 003 WB; tested species: mouse

Cerebellum-Specific Deletion of the GABAA Receptor δ Subunit Leads to Sex-Specific Disruption of Behavior.
Rudolph S, Guo C, Pashkovski SL, Osorno T, Gillis WF, Krauss JM, Nyitrai H, Flaquer I, El-Rifai M, Datta SR, Regehr WG, et al.
Cell reports (2020) 335: 108338. 224 003 WB; tested species: mouse

Receptor protein tyrosine phosphatase delta is not essential for synapse maintenance or transmission at hippocampal synapses.
Han KA, Lee HY, Lim D, Shin J, Yoon TH, Liu X, Um JW, Choi SY, Ko J
Molecular brain (2020) 131: 94. 224 003 WB, ICC; tested species: mouse

Calsyntenin-3 interacts with both α- and β-neurexins in the regulation of excitatory synaptic innervation in specific Schaffer collateral pathways.
Kim H, Kim D, Kim J, Lee HY, Park D, Kang H, Matsuda K, Sterky FH, Yuzaki M, Kim JY, Choi SY, et al.
The Journal of biological chemistry (2020) : . 224 003 WB, IHC; tested species: mouse

Aberrant expression of S-SCAM causes the loss of GABAergic synapses in hippocampal neurons.
Shin SM, Skaar S, Danielson E, Lee SH
Scientific reports (2020) 101: 83. 224 003 WB, ICC; tested species: rat

The small GTPase ARF6 regulates GABAergic synapse development.
Kim H, Jung H, Jung H, Kwon SK, Ko J, Um JW
Molecular brain (2020) 131: 2. 224 003 WB, ICC, IHC; tested species: rat

Diazepam Accelerates GABAAR Synaptic Exchange and Alters Intracellular Trafficking.
Lorenz-Guertin JM, Bambino MJ, Das S, Weintraub ST, Jacob TC
Frontiers in cellular neuroscience (2019) 13: 163. 224 003 WB, IP, ICC; tested species: rat

LMAN1 (ERGIC-53) promotes trafficking of neuroreceptors.
Fu YL, Zhang B, Mu TW
Biochemical and biophysical research communications (2019) : . 224 003 WB; tested species: mouse

Reciprocal control of excitatory synapse numbers by Wnt and Wnt inhibitor PRR7 secreted on exosomes.
Lee SH, Shin SM, Zhong P, Kim HT, Kim DI, Kim JM, Do Heo W, Kim DW, Yeo CY, Kim CH, Liu QS, et al.
Nature communications (2018) 91: 3434. 224 003 WB, ICC; tested species: rat

Activating Transcription Factor 4 (ATF4) regulates neuronal activity by controlling GABABR trafficking.
Corona C, Pasini S, Liu J, Amar F, Greene LA, Shelanski ML
The Journal of neuroscience : the official journal of the Society for Neuroscience (2018) : . 224 003 WB; tested species: rat

GABAAand GABABreceptor subunit localization on neurochemically identified neurons of the human subthalamic nucleus.
Wu XH, Song JJ, Faull RLM, Waldvogel HJ
The Journal of comparative neurology (2018) 5265: 803-823. 224 003 WB, IHC; tested species: human

Molecular Characterization of GABA-A Receptor Subunit Diversity within Major Peripheral Organs and Their Plasticity in Response to Early Life Psychosocial Stress.
Everington EA, Gibbard AG, Swinny JD, Seifi M
Frontiers in molecular neuroscience (2018) 11: 18. 224 003 WB; tested species: mouse

IgSF21 promotes differentiation of inhibitory synapses via binding to neurexin2α.
Tanabe Y, Naito Y, Vasuta C, Lee AK, Soumounou Y, Linhoff MW, Takahashi H
Nature communications (2017) 81: 408. 224 003 WB

γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.
Brown LE, Nicholson MW, Arama JE, Mercer A, Thomson AM, Jovanovic JN
The Journal of biological chemistry (2016) 29127: 13926-42. 224 003 WB

Interferon-γ enhances neocortical synaptic inhibition by promoting membrane association and phosphorylation of GABAA receptors in a protein kinase C-dependent manner.
Janach GMS, Böhm M, Döhne N, Kim HR, Rosário M, Strauss U
Brain, behavior, and immunity (2022) 101: 153-164. 224 003 IP; tested species: rat

Interaction between Teneurin-2 and microtubules via EB proteins provides a platform for GABAA receptor exocytosis.
Ichinose S, Susuki Y, Hosoi N, Kaneko R, Ebihara M, Hirai H, Iwasaki H
eLife (2023) 12: . 224 003 ICC; tested species: mouse

Conformational state-dependent regulation of GABAA receptor diffusion and subsynaptic domains.
Merlaud Z, Marques X, Russeau M, Saade U, Tostain M, Moutkine I, Gielen M, Corringer PJ, Lévi S
iScience (2022) 2511: 105467. 224 003 ICC; tested species: rat

SLITRK2 variants associated with neurodevelopmental disorders impair excitatory synaptic function and cognition in mice.
El Chehadeh S, Han KA, Kim D, Jang G, Bakhtiari S, Lim D, Kim HY, Kim J, Kim H, Wynn J, Chung WK, et al.
Nature communications (2022) 131: 4112. 224 003 ICC; tested species: mouse

Pharmacological activation of ATF6 remodels the proteostasis network to rescue pathogenic GABAA receptors.
Wang M, Cotter E, Wang YJ, Fu X, Whittsette AL, Lynch JW, Wiseman RL, Kelly JW, Keramidas A, Mu TW
Cell & bioscience (2022) 121: 48. 224 003 ICC; tested species: human

Npas4 regulates IQSEC3 expression in hippocampal somatostatin interneurons to mediate anxiety-like behavior.
Kim S, Park D, Kim J, Kim D, Kim H, Mori T, Jung H, Lee D, Hong S, Jeon J, Tabuchi K, et al.
Cell reports (2021) 363: 109417. 224 003 ICC; tested species: mouse

LAR-RPTPs Directly Interact with Neurexins to Coordinate Bidirectional Assembly of Molecular Machineries.
Han KA, Kim YJ, Yoon TH, Kim H, Bae S, Um JW, Choi SY, Ko J
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) : . 224 003 ICC; tested species: mouse

Combined Effect of Midazolam and Bone Morphogenetic Protein-2 for Differentiation Induction from C2C12 Myoblast Cells to Osteoblasts.
Hidaka Y, Chiba-Ohkuma R, Karakida T, Onuma K, Yamamoto R, Fujii-Abe K, Saito MM, Yamakoshi Y, Kawahara H
Pharmaceutics (2020) 123: . 224 003 ICC; tested species: mouse

Loss of IQSEC3 Disrupts GABAergic Synapse Maintenance and Decreases Somatostatin Expression in the Hippocampus.
Kim S, Kim H, Park D, Kim J, Hong J, Kim JS, Jung H, Kim D, Cheong E, Ko J, Um JW, et al.
Cell reports (2020) 306: 1995-2005.e5. 224 003 ICC, IHC; tested species: mouse

The small GTPase ARF6 regulates GABAergic synapse development.
Kim H, Jung H, Jung H, Kwon SK, Ko J, Um JW
Molecular brain (2020) 131: 2. 224 003 WB, ICC, IHC; tested species: rat

Essential role for InSyn1 in dystroglycan complex integrity and cognitive behaviors in mice.
Uezu A, Hisey E, Kobayashi Y, Gao Y, Bradshaw TW, Devlin P, Rodriguiz R, Tata PR, Soderling S
eLife (2019) 8: . 224 003 ICC; tested species: mouse

Clptm1 Limits Forward Trafficking of GABAA Receptors to Scale Inhibitory Synaptic Strength.
Ge Y, Kang Y, Cassidy RM, Moon KM, Lewis R, Wong ROL, Foster LJ, Craig AM
Neuron (2018) 973: 596-610.e8. 224 003 ICC, IHC; tested species: mouse

The Autism-Related Protein PX-RICS Mediates GABAergic Synaptic Plasticity in Hippocampal Neurons and Emotional Learning in Mice.
Nakamura T, Sakaue F, Nasu-Nishimura Y, Takeda Y, Matsuura K, Akiyama T
EBioMedicine (2018) : . 224 003 ICC; tested species: mouse

Depolarizing, inhibitory GABA type A receptor activity regulates GABAergic synapse plasticity via ERK and BDNF signaling.
Brady ML, Pilli J, Lorenz-Guertin JM, Das S, Moon CE, Graff N, Jacob TC
Neuropharmacology (2018) 128: 324-339. 224 003 ICC; tested species: rat

Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 224 003 ICC; tested species: mouse

GARLH Family Proteins Stabilize GABAA Receptors at Synapses.
Yamasaki T, Hoyos-Ramirez E, Martenson JS, Morimoto-Tomita M, Tomita S
Neuron (2017) 935: 1138-1152.e6. 224 003 ICC, IHC; tested species: mouse

Developmentally dynamic colocalization patterns of DSCAM with adhesion and synaptic proteins in the mouse retina.
de Andrade GB, Kunzelman L, Merrill MM, Fuerst PG
Molecular vision (2014) 20: 1422-33. 224 003 ICC, IHC

Identification and characterization of GABA(A) receptor autoantibodies in autoimmune encephalitis.
Ohkawa T, Satake S, Yokoi N, Miyazaki Y, Ohshita T, Sobue G, Takashima H, Watanabe O, Fukata Y, Fukata M
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3424: 8151-63. 224 003 ICC; tested species: rat

Selective control of inhibitory synapse development by Slitrk3-PTPδ trans-synaptic interaction.
Takahashi H, Katayama K, Sohya K, Miyamoto H, Prasad T, Matsumoto Y, Ota M, Yasuda H, Tsumoto T, Aruga J, Craig AM, et al.
Nature neuroscience (2012) 153: 389-98, S1-2. 224 003 ICC

Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes.
Mendu SK, Bhandage A, Jin Z, Birnir B
PloS one (2012) 78: e42959. 224 003 ICC

Molecular motor KIF5A is essential for GABA(A) receptor transport, and KIF5A deletion causes epilepsy.
Nakajima K, Yin X, Takei Y, Seog DH, Homma N, Hirokawa N
Neuron (2012) 765: 945-61. 224 003 ICC

Inhibitory synapse dynamics: coordinated presynaptic and postsynaptic mobility and the major contribution of recycled vesicles to new synapse formation.
Dobie FA, Craig AM
The Journal of neuroscience : the official journal of the Society for Neuroscience (2011) 3129: 10481-93. 224 003 ICC

A readily retrievable pool of synaptic vesicles.
Hua Y, Sinha R, Thiel CS, Schmidt R, Hüve J, Martens H, Hell SW, Egner A, Klingauf J
Nature neuroscience (2011) 147: 833-9. 224 003 ICC

Selected SALM (synaptic adhesion-like molecule) family proteins regulate synapse formation.
Mah W, Ko J, Nam J, Han K, Chung WS, Kim E
The Journal of neuroscience : the official journal of the Society for Neuroscience (2010) 3016: 5559-68. 224 003 ICC

LHFPL5 is a key element in force transmission from the tip link to the hair cell mechanotransducer channel.
Beurg M, Schwalbach ET, Fettiplace R
Proceedings of the National Academy of Sciences of the United States of America (2024) 1213: e2318270121. 224 003 IHC; tested species: mouse

LPS induces microglial activation and GABAergic synaptic deficits in the hippocampus accompanied by prolonged cognitive impairment.
Jung H, Lee D, You H, Lee M, Kim H, Cheong E, Um JW
Scientific reports (2023) 131: 6547. 224 003 IHC; tested species: mouse

Loss of KCC2 in GABAergic Neurons Causes Seizures and an Imbalance of Cortical Interneurons.
Zavalin K, Hassan A, Fu C, Delpire E, Lagrange AH
Frontiers in molecular neuroscience (2022) 15: 826427. 224 003 IHC; tested species: mouse

Identification of intraneuronal amyloid beta oligomers in locus coeruleus neurons of Alzheimer's patients and their potential impact on inhibitory neurotransmitter receptors and neuronal excitability.
Kelly L, Seifi M, Ma R, Mitchell SJ, Rudolph U, Viola KL, Klein WL, Lambert JJ, Swinny JD
Neuropathology and applied neurobiology (2021) 474: 488-505. 224 003 IHC; tested species: mouse

Transient expression of a GABA receptor subunit during early development is critical for inhibitory synapse maturation and function.
Sinha R, Grimes WN, Wallin J, Ebbinghaus BN, Luu K, Cherry T, Rieke F, Rudolph U, Wong RO, Hoon M
Current biology : CB (2021) 3119: 4314-4326.e5. 224 003 IHC; tested species: mouse

PUPIL enables mapping and stamping of transient electrical connectivity in developing nervous systems.
Xie S, Li H, Yao F, Huang J, Yang X, Chen X, Liu Q, Zhuang M, He S
Cell reports (2021) 373: 109853. 224 003 IHC; tested species: mouse

The Effects of General Anaesthesia and Light on Behavioural Rhythms and GABAA Receptor Subunit Expression in the Mouse SCN.
Chong J, Cheeseman JF, Pawley MDM, Kwakowsky A, Warman GR
Clocks & sleep (2021) 33: 482-494. 224 003 IHC; tested species: mouse

Seizure progression triggered by IQSEC3 loss is mitigated by reducing activated microglia in mice.
Park D, Kim S, Kim H, Shin J, Jung H, Um JW
Glia (2020) 6812: 2661-2673. 224 003 IHC; tested species: mouse

Cerebellar molecular layer interneurons are dispensable for cued and contextual fear conditioning.
Marshall-Phelps KLH, Riedel G, Wulff P, Woloszynowska-Fraser M
Scientific reports (2020) 101: 20000. 224 003 IHC; tested species: mouse

The small GTPase ARF6 regulates GABAergic synapse development.
Kim H, Jung H, Jung H, Kwon SK, Ko J, Um JW
Molecular brain (2020) 131: 2. 224 003 WB, ICC, IHC; tested species: rat

GABAergic deficits and schizophrenia-like behaviors in a mouse model carrying patient-derived neuroligin-2 R215H mutation.
Jiang DY, Wu Z, Forsyth CT, Hu Y, Yee SP, Chen G
Molecular brain (2018) 111: 31. 224 003 IHC; tested species: mouse

Spatiotemporal Distribution of GABAA Receptor Subunits Within Layer II of Mouse Medial Entorhinal Cortex: Implications for Grid Cell Excitability.
Berggaard N, Seifi M, van der Want JJL, Swinny JD
Frontiers in neuroanatomy (2018) 12: 46. 224 003 IHC; tested species: mouse

Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells.
Kerti-Szigeti K, Nusser Z
eLife (2016) 5: . 224 003 IHC, EM

GABAA receptor-mediated input change on orexin neurons following sleep deprivation in mice.
Matsuki T, Takasu M, Hirose Y, Murakoshi N, Sinton CM, Motoike T, Yanagisawa M
Neuroscience (2015) 284: 217-24. 224 003 IHC

Phasic, nonsynaptic GABA-A receptor-mediated inhibition entrains thalamocortical oscillations.
Rovó Z, Mátyás F, Barthó P, Slézia A, Lecci S, Pellegrini C, Astori S, Dávid C, Hangya B, Lüthi A, Acsády L, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3421: 7137-47. 224 003 IHC; KO verified; tested species: mouse

Molecular and functional diversity of GABA-A receptors in the enteric nervous system of the mouse colon.
Seifi M, Brown JF, Mills J, Bhandari P, Belelli D, Lambert JJ, Rudolph U, Swinny JD
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3431: 10361-78. 224 003 IHC

Differential GABAergic and glycinergic inputs of inhibitory interneurons and Purkinje cells to principal cells of the cerebellar nuclei.
Husson Z, Rousseau CV, Broll I, Zeilhofer HU, Dieudonné S
The Journal of neuroscience : the official journal of the Society for Neuroscience (2014) 3428: 9418-31. 224 003 IHC; tested species: mouse

Parvalbumin-containing chandelier and basket cell boutons have distinctive modes of maturation in monkey prefrontal cortex.
Fish KN, Hoftman GD, Sheikh W, Kitchens M, Lewis DA
The Journal of neuroscience : the official journal of the Society for Neuroscience (2013) 3319: 8352-8. 224 003 IHC

Amacrine and bipolar inputs to midget and parasol ganglion cells in marmoset retina.
Abbott CJ, Percival KA, Martin PR, Grünert U
Visual neuroscience (2012) 293: 157-68. 224 003 IHC; tested species: marmoset

Setting the time course of inhibitory synaptic currents by mixing multiple GABA(A) receptor α subunit isoforms.
Eyre MD, Renzi M, Farrant M, Nusser Z
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3217: 5853-67. 224 003 IHC

Proliferation of external globus pallidus-subthalamic nucleus synapses following degeneration of midbrain dopamine neurons.
Fan KY, Baufreton J, Surmeier DJ, Chan CS, Bevan MD
The Journal of neuroscience : the official journal of the Society for Neuroscience (2012) 3240: 13718-28. 224 003 IHC

NMDA receptors in GABAergic synapses during postnatal development.
Cserép C, Szabadits E, Szőnyi A, Watanabe M, Freund TF, Nyiri G
PloS one (2012) 75: e37753. 224 003 IHC; tested species: mouse

A subcortical inhibitory signal for behavioral arrest in the thalamus.
Giber K, Diana MA, Plattner V, Dugué GP, Bokor H, Rousseau CV, Maglóczky Z, Havas L, Hangya B, Wildner H, Zeilhofer HU, et al.
Nature neuroscience (2015) 184: 562-568. 224 003 IHC-P; tested species: mouse

Functional Neuroligin-2-MDGA1 interactions differentially regulate synaptic GABAARs and cytosolic gephyrin aggregation.
Zeppillo T, Ali H, Ravichandran S, Ritter TC, Wenger S, López-Murcia FJ, Gideons E, Signorelli J, Schmeisser MJ, Wiltfang J, Rhee J, et al.
Communications biology (2024) 71: 1157. 224 003 IHC-Fr; tested species: mouse

Glyoxal fixation: An approach to solve immunohistochemical problem in neuroscience research.
Konno K, Yamasaki M, Miyazaki T, Watanabe M
Science advances (2023) 928: eadf7084. 224 003 IHC-G; tested species: mouse

Amyloid β induces interneuron-specific changes in the hippocampus of APPNL-F mice.
Sos KE, Mayer MI, Takács VT, Major A, Bardóczi Z, Beres BM, Szeles T, Saito T, Saido TC, Mody I, Freund TF, et al.
PloS one (2020) 155: e0233700. 224 003 EM; tested species: mouse

Structural and Functional Remodeling of Amygdala GABAergic Synapses in Associative Fear Learning.
Kasugai Y, Vogel E, Hörtnagl H, Schönherr S, Paradiso E, Hauschild M, Göbel G, Milenkovic I, Peterschmitt Y, Tasan R, Sperk G, et al.
Neuron (2019) 1044: 781-794.e4. 224 003 EM; tested species: mouse

Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells.
Kerti-Szigeti K, Nusser Z
eLife (2016) 5: . 224 003 IHC, EM

The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors.
Whittsette AL, Wang YJ, Mu TW
iScience (2022) 258: 104754. 224 003 WB, UPTAKE; tested species: rat

Fast Regulation of GABAAR Diffusion Dynamics by Nogo-A Signaling.
Fricke S, Metzdorf K, Ohm M, Haak S, Heine M, Korte M, Zagrebelsky M
Cell reports (2019) 293: 671-684.e6. 224 003 UPTAKE; tested species: mouse

Cat. No.: 224 003

Amount: 50 µg

Price: $400.00

The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors.
Whittsette AL, Wang YJ, Mu TW
iScience (2022) 258: 104754. 224 003 WB, UPTAKE; tested species: rat

The small GTPase ARF6 regulates GABAergic synapse development.
Kim H, Jung H, Jung H, Kwon SK, Ko J, Um JW
Molecular brain (2020) 131: 2. 224 003 WB, ICC, IHC; tested species: rat

LMAN1 (ERGIC-53) promotes trafficking of neuroreceptors.
Fu YL, Zhang B, Mu TW
Biochemical and biophysical research communications (2019) : . 224 003 WB; tested species: mouse

The small GTPase ARF6 regulates GABAergic synapse development.
Kim H, Jung H, Jung H, Kwon SK, Ko J, Um JW
Molecular brain (2020) 131: 2. 224 003 WB, ICC, IHC; tested species: rat

Different subtypes of GABA-A receptors are expressed in human, mouse and rat T lymphocytes.
Mendu SK, Bhandage A, Jin Z, Birnir B
PloS one (2012) 78: e42959. 224 003 ICC

A readily retrievable pool of synaptic vesicles.
Hua Y, Sinha R, Thiel CS, Schmidt R, Hüve J, Martens H, Hell SW, Egner A, Klingauf J
Nature neuroscience (2011) 147: 833-9. 224 003 ICC

The small GTPase ARF6 regulates GABAergic synapse development.
Kim H, Jung H, Jung H, Kwon SK, Ko J, Um JW
Molecular brain (2020) 131: 2. 224 003 WB, ICC, IHC; tested species: rat

Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells.
Kerti-Szigeti K, Nusser Z
eLife (2016) 5: . 224 003 IHC, EM

NMDA receptors in GABAergic synapses during postnatal development.
Cserép C, Szabadits E, Szőnyi A, Watanabe M, Freund TF, Nyiri G
PloS one (2012) 75: e37753. 224 003 IHC; tested species: mouse

Similar GABAA receptor subunit composition in somatic and axon initial segment synapses of hippocampal pyramidal cells.
Kerti-Szigeti K, Nusser Z
eLife (2016) 5: . 224 003 IHC, EM

The endoplasmic reticulum membrane complex promotes proteostasis of GABAA receptors.
Whittsette AL, Wang YJ, Mu TW
iScience (2022) 258: 104754. 224 003 WB, UPTAKE; tested species: rat

ICC

IHC

Background

Gamma-aminobutyric acid type A (GABA-A) receptors mediate the majority of inhibitory neurotransmission in the brain. These receptor proteins are ligand gated chloride ion channels and consist of a pentameric combination of different subunits (alpha, beta, gamma, delta, epsilon and rho). The resulting heterogenous population of GABA-A receptor subtypes are expressed throughout the brain with specific cellular and subcellular expression patterns.

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3 ) Kralic JE et al., J. Comp. Neurol. (2006)
4 ) Essrich C et al., Nat. Neurosci. (1998)
5 ) Fritschy JM et al., J. Comp. Neurol. (1995)
6 ) Benke D et al., J. Biol. Chem. (1994)
7 ) Fritschy JM et al., Proc. Natl. Acad. Sci. U.S.A. (1992)

Protocols

Standard protocol

ICC

IHC

OTHER

Preabsorbtion

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GABA-A receptor gamma2 antibody extracellular - 224 003 K.O.

References for GABA-A receptor gamma2 - 224 003