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Abeta 38/40/42/43 - 218 711

A major component of neuritic plaques in Alzheimer's disease
Monoclonal mouse purified IgG
Cat. No.: 218 711
Amount: 100 µg
Price: 415.00 €
Cat. No. 218 711 100 µg purified IgG, lyophilized. Azide was added before lyophilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C until use.
Applications WB: not tested yet
IP: not tested yet
ICC: not tested yet
IHC: 1 : 100 up to 1 : 500 (see remarks) gallery  
IHC-P/FFPE: 1 : 500 (see remarks) gallery  
Clone 88B12
Subtype IgG2b (κ light chain)
Immunogen Synthetic peptide corresponding to AA 17 to 26 from human Abeta (UniProt Id: P05067)
Epitop Epitop: AA 17 to 26 from human Abeta (UniProt Id: P05067)
Reactivity Reacts with: human (P05067), mouse (P12023).
Other species not tested yet.
Specificity Specific for Abeta 38, 40, 42.
Remarks

IHC: Antigen retrieval with formic acid is required.

IHC-P: Antigen retrieval with formic acid is required.

Data sheet 218_711.pdf

References for Abeta 38/40/42/43 - 218 711

Female Mice with Apolipoprotein E4 Domain Interaction Demonstrated Impairments in Spatial Learning and Memory Performance and Disruption of Hippocampal Cyto-Architecture.
Adeosun SO, Hou X, Shi L, Stockmeier CA, Zheng B, Raffai RL, Weisgraber KH, Mosley TH, Ming Wang J
Neurobiology of learning and memory (2019) : . 218 711 DOTBLOT; tested species: mouse
Cat. No.: 218 711
Quantity: 100 µg
Price: 415.00 €
Female Mice with Apolipoprotein E4 Domain Interaction Demonstrated Impairments in Spatial Learning and Memory Performance and Disruption of Hippocampal Cyto-Architecture.
Adeosun SO, Hou X, Shi L, Stockmeier CA, Zheng B, Raffai RL, Weisgraber KH, Mosley TH, Ming Wang J
Neurobiology of learning and memory (2019) : . 218 711 DOTBLOT; tested species: mouse
Background

Amyloid deposits, also called plaques, of Alzheimer's patients consist of several protein components like the amyloid beta-peptides (Abeta, Aβ) 1-40/42/43 and additional C- and N-terminally modified fragments of Abeta as for instance Abeta pE3 and Abeta pE11.
An additional Abeta variant, Abeta 38, is more soluble compared to other Abeta species and is not found in plaques of sporadic Alzheimer´s cases. However, it is detected in the blood-vessel walls of a subset of patients with severe cerebral amyloid angiopathy. It especially accumulates in brains of patients carrying mutations in the Abeta coding region.
Cleavage of amyloid precursor protein APP by β- and γ- secretases results in the generation of the Aβ (βA4)peptide, whereas α-secretase cleaves within the Aβ sequence and prevents the formation of Abeta from APP.