|Cat. No. 214 011C5||
100 µg purified IgG, lyophilized, fluorescence-labeled with Oyster® 650
Fluorescence labeled antibodies conjugated to Oyster dyes from
Oyster dyes, Oyster-488, Oyster-500, Oyster-550, and Oyster-650 are trademarks of Luminartis GmbH, Muenster/Germany.
CyDyes, Cy2, Cy3, and Cy5 are trademarks of GE-Healthcare Ltd.
Reconstitute immediately upon receipt! Avoid bright light when working with the antibody to minimize photo bleeching of the fluorescent dye.The mounting agent Aquatex®(Merck Chemicals) is not compatible with Oyster dyes!
ICC: not tested yet
IHC: 1 : 200 gallery
IHC-P/FFPE: not tested yet
|Subtype||IgG1 (κ light chain)|
|Immunogen||Recombinant protein corresponding to AA 3 to 251 from human CalbindinD28k (UniProt Id: P05937)|
Epitop: AA 3 to 251 from human CalbindinD28k (UniProt Id: P05937)
Reacts with: human (P05937), rat (P07171), mouse (P12658), zebrafish.
Other species not tested yet.
|Specificity||Specific for calbindin D28k.|
|Matching control protein/peptide||214-0P|
Two isoforms of the vitamin D-dependent Ca-binding proteins have been described so far: calbindin D28k, also referred to as CALB 1, D-28k, and CAB 27, and calbindin D29k, also known as calretinin. These proteins are expressed in cells that have to handle a high calcium influx such as brain, bone, teeth, inner ear and others. Calbindins are believed to regulate cellular activity by suppressing or buffering intracellur calcium. In the brain calbindin D28k is a useful marker for specific neuronal cell types. It is particularly concentrated in the dendrites and perikarya of cerebellar Purkinje cells, but is also found in many GABAergic interneurons in the cortex.