Synaptic Systems

Cat. No.: 202 111

Amount: 100 µg

Price: $435.00

Cat. No. 202 111	100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H₂O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	Dot blot: 1 : 1000 gallery IP: yes ICC: not tested yet IHC: not tested yet IHC-P: not tested yet ELISA: yes gallery MeRIP: yes
Clone	212B11
Subtype	IgG2b (κ light chain)
Immunogen	N6-methyladenosine fused to BSA.
Reactivity	Reacts with: human, rat, mouse, eukaryotes, prokaryotes. Other species not tested yet.
Specificity	Specific for N6-methyladenosine (m6A) with some cross-reactivity to m6Am.
Data sheet	202_111.pdf

mRNA stability and m6A are major determinants of subcellular mRNA localization in neurons.
Loedige I, Baranovskii A, Mendonsa S, Dantsuji S, Popitsch N, Breimann L, Zerna N, Cherepanov V, Milek M, Ameres S, Chekulaeva M, et al.
Molecular cell (2023) 8315: 2709-2725.e10. 202 111 Dot blot; tested species: mouse

A Neuroligin-1 mutation associated with Alzheimer's disease produces memory and age-dependent impairments in hippocampal plasticity.
Arias-Aragón F, Tristán-Clavijo E, Martínez-Gallego I, Robles-Lanuza E, Coatl-Cuaya H, Martín-Cuevas C, Sánchez-Hidalgo AC, Rodríguez-Moreno A, Martinez-Mir A, Scholl FG
iScience (2023) 266: 106868. 202 111 Dot blot

Evaluation of N 6-methyldeoxyadenosine antibody-based genomic profiling in eukaryotes.
Debo BM, Mallory BJ, Stergachis AB
Genome research (2023) 333: 427-434. 202 111 Dot blot

A lncRNA from the FTO locus acts as a suppressor of the m6A writer complex and p53 tumor suppression signaling.
Zhang J, Wei J, Sun R, Sheng H, Yin K, Pan Y, Jimenez R, Chen S, Cui XL, Zou Z, Yue Z, et al.
Molecular cell (2023) 8315: 2692-2708.e7. 202 111 Dot blot, MeRIP; tested species: mouse

N6-methyladenosine (m6A) RNA methylation mediated by methyltransferase complex subunit WTAP regulates amelogenesis.
Xie F, Zhu X, Liu X, Chen H, Wang J
The Journal of biological chemistry (2022) : 102715. 202 111 Dot blot

Enterotoxigenic Escherichia coli infection promotes enteric defensin expression via FOXO6-METTL3-m6A-GPR161 signalling axis.
Zong X, Wang H, Xiao X, Zhang Y, Hu Y, Wang F, Wang Y, Lu Z
RNA biology (2020) : 1-11. 202 111 Dot blot, MeRIP; tested species: pig

Direct RNA sequencing enables m6A detection in endogenous transcript isoforms at base specific resolution.
Lorenz DA, Sathe S, Einstein JM, Yeo GW
RNA (New York, N.Y.) (2019) : . 202 111 Dot blot; tested species: human

Epitranscriptomic m6A Regulation of Axon Regeneration in the Adult Mammalian Nervous System.
Weng YL, Wang X, An R, Cassin J, Vissers C, Liu Y, Liu Y, Xu T, Wang X, Wong SZH, Joseph J, et al.
Neuron (2018) 972: 313-325.e6. 202 111 Dot blot; tested species: mouse

Transcriptional Dysregulation in Postnatal Glutamatergic Progenitors Contributes to Closure of the Cortical Neurogenic Period.
Donega V, Marcy G, Lo Giudice Q, Zweifel S, Angonin D, Fiorelli R, Abrous DN, Rival-Gervier S, Koehl M, Jabaudon D, Raineteau O, et al.
Cell reports (2018) 2210: 2567-2574. 202 111 Dot blot

Temporal Control of Mammalian Cortical Neurogenesis by m6A Methylation.
Yoon KJ, Ringeling FR, Vissers C, Jacob F, Pokrass M, Jimenez-Cyrus D, Su Y, Kim NS, Zhu Y, Zheng L, Kim S, et al.
Cell (2017) 1714: 877-889.e17. 202 111 Dot blot

Cat. No.: 202 111

Amount: 100 µg

Price: $435.00

Dot blot

ELISA

Background

Protocols

m6A antibody - 202 111