Cat. No.: 198 211
Amount: 100 µg
Price:
$420.00
|
|
|
| Cat. No. 198 211 |
100 µg purified IgG, lyophilized. Albumin and azide were added for stabilization. For reconstitution add 100 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
| Applications | |
| Clone | 126G12 |
| Subtype | IgG2b (κ light chain) |
| Immunogen | Recombinant protein corresponding to residues near the amino-terminus of mouse GAD1. (UniProt Id: P48318) |
| Epitop |
Epitop: AA 94 to 101 from mouse GAD1 (UniProt Id: P48318) |
| Reactivity |
Reacts with: mouse (P48318), rat (P18088). Other species not tested yet. |
| Specificity | Specific for GAD 1 / GAD67. |
| Remarks |
This antibody is highly recommened for Western blot and IF. |
| Data sheet | 198_211.pdf |
|
|
The glutamic acid decarboxylases GAD 1, also referred to as GAD 67, and GAD 2 / GAD 65 synthesize γ-aminobutyric acid (GABA), the major inhibitory neurotransmitter in the central nervous system. The hydrophilic GAD 1 can heterodimerize with the membrane achored GAD 2 and part of GAD 1 is targeted to inhibitory nerve terminals by this mechanisms. Although both proteins exhibit significant differences in their N-terminus they share high homology in the rest of the molecule.
GADs are widely used markers for the GABAergic system. In type 1 diabetes GAD 1 has been identified as a major autoantigen.