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Home > Products > 195 002

Parvalbumin antibody - 195 002

Parvalbumin is calcium binding protein specific for a subpopulation of GABAergic interneurones
Rabbit polyclonal antiserum
Cat. No.: 195 002
Amount: 200 µl
Price: $360.00
Cat. No. 195 002 200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.
Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications
 
WB: 1 : 5000 up to 1 : 10000 (AP staining) (see remarks) gallery  
IP: yes
ICC: not tested yet
IHC: 1 : 500 up to 1 : 1000 gallery  
IHC-P: 1 : 500 gallery  

Western blot (WB); separation of proteins by PAGE and subsequent transfer to a membrane. Detection of target molecules is carried out with antibodies. Some antibodies require special sample preparation steps. For details, please refer to the “Remarks” section.

Immunoprecipitation (IP); Immunoisolation or pulldown of a target molecule using an antibody. For details and product specific hints, please refer to the ”Remarks” section.

Immunocytochemistry (ICC) on 4% PFA fixed cells. Immunoreactivity is usually revealed by fluorescence. Some antibodies require special fixation methods. For details, please refer to the “Remarks” section.

Immunohistochemistry (IHC) on 4% PFA perfusion fixed tissue with 24h PFA post fixation. Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate. Some antibodies require special fixation methods or antigen retrieval steps. For details, please refer to the ”Remarks” section.

Immunohistochemistry (IHC-P) of formalin fixed, paraffin embedded (FFPE) tissue (some antibodies require special antigen retrieval steps, please refer to the ”Remarks” section). Immunoreactivity is usually revealed by fluorescence or a chromogenic substrate.
Immunogen Full-length recombinant rat Parvalbumin (UniProt Id: P02625)
Reactivity Reacts with: human (P20472), rat (P02625), mouse (P32848), grashopper.
Other species not tested yet.
Matching control protein/peptide 195-0P
Remarks

WB: Due to its small size a tricine gel is recommended.
Data sheet 195_002.pdf

References for Parvalbumin - 195 002

Repeated Blockade of NMDA Receptors During Adolescence Impairs Reversal Learning and Disrupts GABAergic Interneurons in Rat Medial Prefrontal Cortex.
Li JT, Su YA, Wang HL, Zhao YY, Liao XM, Wang XD, Si TM
Frontiers in molecular neuroscience (2016) 9: 17. 195 002 WB
Absence of aquaporin-4 in skeletal muscle alters proteins involved in bioenergetic pathways and calcium handling.
Basco D, Nicchia GP, D'Alessandro A, Zolla L, Svelto M, Frigeri A
PloS one (2011) 64: e19225. 195 002 WB; tested species: mouse
Long-Term Cultures of Spinal Cord Interneurons.
Vargova I, Kriska J, Kwok JCF, Fawcett JW, Jendelova P
Frontiers in cellular neuroscience (2022) 16: 827628. 195 002 ICC; tested species: mouse
Activity-dependent PI4P synthesis by PI4KIIIα regulates long-term synaptic potentiation.
Guo Z, Jiang CH, Tong C, Yang Y, Wang Z, Lam SM, Wang D, Li R, Shui G, Shi YS, Liu JJ, et al.
Cell reports (2022) 389: 110452. 195 002 ICC; tested species: mouse
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 195 002 ICC; tested species: mouse
MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus.
Yang FC, Vivian JL, Traxler C, Shapiro SM, Stanford JA
Cell transplantation () 31: 9636897221101116. 195 002 ICC, IHC; tested species: human,rat
Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.
Michanski S, Kapoor R, Steyer AM, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra FK, Neef J, Strenzke N, et al.
EMBO reports (2023) 249: e56702. 195 002 IHC; tested species: rat
Loss of the parkinsonism-associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects.
Wang J, Joseph S, Vingill S, Dere E, Tatenhorst L, Ronnenberg A, Lingor P, Preisinger C, Ehrenreich H, Schulz JB, Stegmüller J, et al.
Journal of neurochemistry (2023) : . 195 002 IHC; tested species: mouse
In vivo optogenetic inhibition of striatal parvalbumin-reactive interneurons induced genotype-specific changes in neuronal activity without dystonic signs in male DYT1 knock-in mice.
Schulz A, Richter F, Richter A
Journal of neuroscience research (2023) 1014: 448-463. 195 002 IHC; tested species: mouse
Inhibition allocates spikes during hippocampal ripples.
Noguchi A, Huszár R, Morikawa S, Buzsáki G, Ikegaya Y
Nature communications (2022) 131: 1280. 195 002 IHC; tested species: mouse
Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy.
Merseburg A, Kasemir J, Buss EW, Leroy F, Bock T, Porro A, Barnett A, Tröder SE, Engeland B, Stockebrand M, Moroni A, et al.
eLife (2022) 11: . 195 002 IHC; tested species: mouse
Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses.
Aldahabi M, Balint F, Holderith N, Lorincz A, Reva M, Nusser Z
Neuron (2022) : . 195 002 IHC; tested species: mouse
Total Number and Ratio of GABAergic Neuron Types in the Mouse Lateral and Basal Amygdala.
Vereczki VK, Müller K, Krizsán É, Máté Z, Fekete Z, Rovira-Esteban L, Veres JM, Erdélyi F, Hájos N
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) 4121: 4575-4595. 195 002 IHC; tested species: mouse
Elevated expression of endogenous glial cell line-derived neurotrophic factor impairs spatial memory performance and raises inhibitory tone in the hippocampus.
Marshall P, Garton DR, Taira T, Võikar V, Vilenius C, Kulesskaya N, Rivera C, Andressoo JO
The European journal of neuroscience (2021) 538: 2469-2482. 195 002 IHC; tested species: mouse
Semilunar granule cells are the primary source of the perisomatic excitatory innervation onto parvalbumin-expressing interneurons in the dentate gyrus.
Rovira-Esteban L, Hájos N, Nagy GA, Crespo C, Nacher J, Varea E, Blasco-Ibáñez JM
eNeuro (2020) : . 195 002 IHC; tested species: mouse
Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain.
Androvic P, Kirdajova D, Tureckova J, Zucha D, Rohlova E, Abaffy P, Kriska J, Valny M, Anderova M, Kubista M, Valihrach L, et al.
Cell reports (2020) 3111: 107777. 195 002 IHC; tested species: mouse
Npas1+-Nkx2.1+ Neurons Are an Integral Part of the Cortico-pallido-cortical Loop.
Abecassis ZA, Berceau BL, Win PH, García D, Xenias HS, Cui Q, Pamukcu A, Cherian S, Hernández VM, Chon U, Lim BK, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 404: 743-768. 195 002 IHC; tested species: mouse
Region-specific interneuron demyelination and heightened anxiety-like behavior induced by adolescent binge alcohol treatment.
Rice J, Coutellier L, Weiner JL, Gu C
Acta neuropathologica communications (2019) 71: 173. 195 002 IHC; tested species: mouse
Ultrafast optogenetic stimulation of the auditory pathway by targeting-optimized Chronos.
Keppeler D, Merino RM, Lopez de la Morena D, Bali B, Huet AT, Gehrt A, Wrobel C, Subramanian S, Dombrowski T, Wolf F, Rankovic V, et al.
The EMBO journal (2018) : . 195 002 IHC; tested species: rat
The neuropathological investigation of the brain in a monkey model of autism spectrum disorder with ABCA13 deletion.
Iritani S, Torii Y, Habuchi C, Sekiguchi H, Fujishiro H, Yoshida M, Go Y, Iriki A, Isoda M, Ozaki N
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2018) : . 195 002 IHC; tested species: monkey
Intravenous infusion of human bone marrow mesenchymal stromal cells promotes functional recovery and neuroplasticity after ischemic stroke in mice.
Sammali E, Alia C, Vegliante G, Colombo V, Giordano N, Pischiutta F, Boncoraglio GB, Barilani M, Lazzari L, Caleo M, De Simoni MG, et al.
Scientific reports (2017) 71: 6962. 195 002 IHC; tested species: mouse
Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep.
Härtig W, Mages B, Aleithe S, Nitzsche B, Altmann S, Barthel H, Krueger M, Michalski D
Frontiers in integrative neuroscience (2017) 11: 15. 195 002 IHC; tested species: mouse,rat
Deletion of CTNNB1 in inhibitory circuitry contributes to autism-associated behavioral defects.
Dong F, Jiang J, McSweeney C, Zou D, Liu L, Mao Y
Human molecular genetics (2016) 2513: 2738-2751. 195 002 IHC
Abolished perineuronal nets and altered parvalbumin-immunoreactivity in the nucleus reticularis thalami of wildtype and 3xTg mice after experimental stroke.
Härtig W, Appel S, Suttkus A, Grosche J, Michalski D
Neuroscience (2016) 337: 66-87. 195 002 IHC
BDNF Depresses Excitability of Parvalbumin-Positive Interneurons through an M-Like Current in Rat Dentate Gyrus.
Nieto-Gonzalez JL, Jensen K
PloS one (2013) 86: e67318. 195 002 IHC
MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus.
Yang FC, Vivian JL, Traxler C, Shapiro SM, Stanford JA
Cell transplantation () 31: 9636897221101116. 195 002 ICC, IHC; tested species: human,rat
Cat. No.: 195 002
Amount: 200 µl
Price: $360.00
Repeated Blockade of NMDA Receptors During Adolescence Impairs Reversal Learning and Disrupts GABAergic Interneurons in Rat Medial Prefrontal Cortex.
Li JT, Su YA, Wang HL, Zhao YY, Liao XM, Wang XD, Si TM
Frontiers in molecular neuroscience (2016) 9: 17. 195 002 WB
Absence of aquaporin-4 in skeletal muscle alters proteins involved in bioenergetic pathways and calcium handling.
Basco D, Nicchia GP, D'Alessandro A, Zolla L, Svelto M, Frigeri A
PloS one (2011) 64: e19225. 195 002 WB; tested species: mouse
Long-Term Cultures of Spinal Cord Interneurons.
Vargova I, Kriska J, Kwok JCF, Fawcett JW, Jendelova P
Frontiers in cellular neuroscience (2022) 16: 827628. 195 002 ICC; tested species: mouse
Activity-dependent PI4P synthesis by PI4KIIIα regulates long-term synaptic potentiation.
Guo Z, Jiang CH, Tong C, Yang Y, Wang Z, Lam SM, Wang D, Li R, Shui G, Shi YS, Liu JJ, et al.
Cell reports (2022) 389: 110452. 195 002 ICC; tested species: mouse
Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 195 002 ICC; tested species: mouse
MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus.
Yang FC, Vivian JL, Traxler C, Shapiro SM, Stanford JA
Cell transplantation () 31: 9636897221101116. 195 002 ICC, IHC; tested species: human,rat
Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.
Michanski S, Kapoor R, Steyer AM, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra FK, Neef J, Strenzke N, et al.
EMBO reports (2023) 249: e56702. 195 002 IHC; tested species: rat
Loss of the parkinsonism-associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects.
Wang J, Joseph S, Vingill S, Dere E, Tatenhorst L, Ronnenberg A, Lingor P, Preisinger C, Ehrenreich H, Schulz JB, Stegmüller J, et al.
Journal of neurochemistry (2023) : . 195 002 IHC; tested species: mouse
In vivo optogenetic inhibition of striatal parvalbumin-reactive interneurons induced genotype-specific changes in neuronal activity without dystonic signs in male DYT1 knock-in mice.
Schulz A, Richter F, Richter A
Journal of neuroscience research (2023) 1014: 448-463. 195 002 IHC; tested species: mouse
Inhibition allocates spikes during hippocampal ripples.
Noguchi A, Huszár R, Morikawa S, Buzsáki G, Ikegaya Y
Nature communications (2022) 131: 1280. 195 002 IHC; tested species: mouse
Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy.
Merseburg A, Kasemir J, Buss EW, Leroy F, Bock T, Porro A, Barnett A, Tröder SE, Engeland B, Stockebrand M, Moroni A, et al.
eLife (2022) 11: . 195 002 IHC; tested species: mouse
Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses.
Aldahabi M, Balint F, Holderith N, Lorincz A, Reva M, Nusser Z
Neuron (2022) : . 195 002 IHC; tested species: mouse
Total Number and Ratio of GABAergic Neuron Types in the Mouse Lateral and Basal Amygdala.
Vereczki VK, Müller K, Krizsán É, Máté Z, Fekete Z, Rovira-Esteban L, Veres JM, Erdélyi F, Hájos N
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) 4121: 4575-4595. 195 002 IHC; tested species: mouse
Elevated expression of endogenous glial cell line-derived neurotrophic factor impairs spatial memory performance and raises inhibitory tone in the hippocampus.
Marshall P, Garton DR, Taira T, Võikar V, Vilenius C, Kulesskaya N, Rivera C, Andressoo JO
The European journal of neuroscience (2021) 538: 2469-2482. 195 002 IHC; tested species: mouse
Semilunar granule cells are the primary source of the perisomatic excitatory innervation onto parvalbumin-expressing interneurons in the dentate gyrus.
Rovira-Esteban L, Hájos N, Nagy GA, Crespo C, Nacher J, Varea E, Blasco-Ibáñez JM
eNeuro (2020) : . 195 002 IHC; tested species: mouse
Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain.
Androvic P, Kirdajova D, Tureckova J, Zucha D, Rohlova E, Abaffy P, Kriska J, Valny M, Anderova M, Kubista M, Valihrach L, et al.
Cell reports (2020) 3111: 107777. 195 002 IHC; tested species: mouse
Npas1+-Nkx2.1+ Neurons Are an Integral Part of the Cortico-pallido-cortical Loop.
Abecassis ZA, Berceau BL, Win PH, García D, Xenias HS, Cui Q, Pamukcu A, Cherian S, Hernández VM, Chon U, Lim BK, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 404: 743-768. 195 002 IHC; tested species: mouse
Region-specific interneuron demyelination and heightened anxiety-like behavior induced by adolescent binge alcohol treatment.
Rice J, Coutellier L, Weiner JL, Gu C
Acta neuropathologica communications (2019) 71: 173. 195 002 IHC; tested species: mouse
Ultrafast optogenetic stimulation of the auditory pathway by targeting-optimized Chronos.
Keppeler D, Merino RM, Lopez de la Morena D, Bali B, Huet AT, Gehrt A, Wrobel C, Subramanian S, Dombrowski T, Wolf F, Rankovic V, et al.
The EMBO journal (2018) : . 195 002 IHC; tested species: rat
The neuropathological investigation of the brain in a monkey model of autism spectrum disorder with ABCA13 deletion.
Iritani S, Torii Y, Habuchi C, Sekiguchi H, Fujishiro H, Yoshida M, Go Y, Iriki A, Isoda M, Ozaki N
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2018) : . 195 002 IHC; tested species: monkey
Intravenous infusion of human bone marrow mesenchymal stromal cells promotes functional recovery and neuroplasticity after ischemic stroke in mice.
Sammali E, Alia C, Vegliante G, Colombo V, Giordano N, Pischiutta F, Boncoraglio GB, Barilani M, Lazzari L, Caleo M, De Simoni MG, et al.
Scientific reports (2017) 71: 6962. 195 002 IHC; tested species: mouse
Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep.
Härtig W, Mages B, Aleithe S, Nitzsche B, Altmann S, Barthel H, Krueger M, Michalski D
Frontiers in integrative neuroscience (2017) 11: 15. 195 002 IHC; tested species: mouse,rat
Deletion of CTNNB1 in inhibitory circuitry contributes to autism-associated behavioral defects.
Dong F, Jiang J, McSweeney C, Zou D, Liu L, Mao Y
Human molecular genetics (2016) 2513: 2738-2751. 195 002 IHC
Abolished perineuronal nets and altered parvalbumin-immunoreactivity in the nucleus reticularis thalami of wildtype and 3xTg mice after experimental stroke.
Härtig W, Appel S, Suttkus A, Grosche J, Michalski D
Neuroscience (2016) 337: 66-87. 195 002 IHC
BDNF Depresses Excitability of Parvalbumin-Positive Interneurons through an M-Like Current in Rat Dentate Gyrus.
Nieto-Gonzalez JL, Jensen K
PloS one (2013) 86: e67318. 195 002 IHC
MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus.
Yang FC, Vivian JL, Traxler C, Shapiro SM, Stanford JA
Cell transplantation () 31: 9636897221101116. 195 002 ICC, IHC; tested species: human,rat
WB
IHC
IHC-P
Background

Parvalbumin is a small, acidic calcium binding protein and belongs to the family of EF hand proteins. The protein is found in skeletal muscle and the brain of vertebrates where it locates to a specific population of GABAergic interneurons. This subset of neurons may contribute to maintaining the balance between excitation and inhibition in the cortex and the hippocampus.
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