Synaptic Systems - Parvalbumin

Cat. No.: 195 002

Amount: 200 µl

Price: $365.00

Cat. No. 195 002	200 µl antiserum, lyophilized. For reconstitution add 200 µl H₂O, then aliquot and store at -20°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze!
Applications	WB: 1 : 5000 up to 1 : 10000 (AP staining) (see remarks) gallery IP: yes ICC: not tested yet IHC: 1 : 500 up to 1 : 1000 gallery IHC-P: 1 : 500 gallery
Immunogen	Full-length recombinant rat Parvalbumin (UniProt Id: P02625)
Reactivity	Reacts with: human (P20472), rat (P02625), mouse (P32848), grashopper. Other species not tested yet.
Matching control protein/peptide	195-0P
Remarks	WB: Due to its small size a tricine gel is recommended.
Data sheet	195_002.pdf

References for Parvalbumin - 195 002

WB (2)
ICC (4)
IHC (21)

Repeated Blockade of NMDA Receptors During Adolescence Impairs Reversal Learning and Disrupts GABAergic Interneurons in Rat Medial Prefrontal Cortex.
Li JT, Su YA, Wang HL, Zhao YY, Liao XM, Wang XD, Si TM
Frontiers in molecular neuroscience (2016) 9: 17. 195 002 WB

Absence of aquaporin-4 in skeletal muscle alters proteins involved in bioenergetic pathways and calcium handling.
Basco D, Nicchia GP, D'Alessandro A, Zolla L, Svelto M, Frigeri A
PloS one (2011) 64: e19225. 195 002 WB; tested species: mouse

Long-Term Cultures of Spinal Cord Interneurons.
Vargova I, Kriska J, Kwok JCF, Fawcett JW, Jendelova P
Frontiers in cellular neuroscience (2022) 16: 827628. 195 002 ICC; tested species: mouse

Activity-dependent PI4P synthesis by PI4KIIIα regulates long-term synaptic potentiation.
Guo Z, Jiang CH, Tong C, Yang Y, Wang Z, Lam SM, Wang D, Li R, Shui G, Shi YS, Liu JJ, et al.
Cell reports (2022) 389: 110452. 195 002 ICC; tested species: mouse

Transient oxytocin signaling primes the development and function of excitatory hippocampal neurons.
Ripamonti S, Ambrozkiewicz MC, Guzzi F, Gravati M, Biella G, Bormuth I, Hammer M, Tuffy LP, Sigler A, Kawabe H, Nishimori K, et al.
eLife (2017) 6: . 195 002 ICC; tested species: mouse

MGE-Like Neural Progenitor Cell Survival and Expression of Parvalbumin and Proenkephalin in a Jaundiced Rat Model of Kernicterus.
Yang FC, Vivian JL, Traxler C, Shapiro SM, Stanford JA
Cell transplantation () 31: 9636897221101116. 195 002 ICC, IHC; tested species: human,rat

Increased seizure susceptibility in thyroid hormone transporter Mct8/Oatp1c1 knockout mice is associated with altered neurotransmitter systems development.
Alcaide Martin A, Bauer R, Führer-Sakel D, Heuer H, Mayerl S
Progress in neurobiology (2025) 247: 102731. 195 002 IHC; tested species: mouse

Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing.
Michanski S, Kapoor R, Steyer AM, Möbius W, Früholz I, Ackermann F, Gültas M, Garner CC, Hamra FK, Neef J, Strenzke N, et al.
EMBO reports (2023) 249: e56702. 195 002 IHC; tested species: rat

Loss of the parkinsonism-associated protein FBXO7 in glutamatergic forebrain neurons in mice leads to abnormal motor behavior and synaptic defects.
Wang J, Joseph S, Vingill S, Dere E, Tatenhorst L, Ronnenberg A, Lingor P, Preisinger C, Ehrenreich H, Schulz JB, Stegmüller J, et al.
Journal of neurochemistry (2023) : . 195 002 IHC; tested species: mouse

In vivo optogenetic inhibition of striatal parvalbumin-reactive interneurons induced genotype-specific changes in neuronal activity without dystonic signs in male DYT1 knock-in mice.
Schulz A, Richter F, Richter A
Journal of neuroscience research (2023) 1014: 448-463. 195 002 IHC; tested species: mouse

Inhibition allocates spikes during hippocampal ripples.
Noguchi A, Huszár R, Morikawa S, Buzsáki G, Ikegaya Y
Nature communications (2022) 131: 1280. 195 002 IHC; tested species: mouse

Seizures, behavioral deficits, and adverse drug responses in two new genetic mouse models of HCN1 epileptic encephalopathy.
Merseburg A, Kasemir J, Buss EW, Leroy F, Bock T, Porro A, Barnett A, Tröder SE, Engeland B, Stockebrand M, Moroni A, et al.
eLife (2022) 11: . 195 002 IHC; tested species: mouse

Different priming states of synaptic vesicles underlie distinct release probabilities at hippocampal excitatory synapses.
Aldahabi M, Balint F, Holderith N, Lorincz A, Reva M, Nusser Z
Neuron (2022) : . 195 002 IHC; tested species: mouse

Total Number and Ratio of GABAergic Neuron Types in the Mouse Lateral and Basal Amygdala.
Vereczki VK, Müller K, Krizsán É, Máté Z, Fekete Z, Rovira-Esteban L, Veres JM, Erdélyi F, Hájos N
The Journal of neuroscience : the official journal of the Society for Neuroscience (2021) 4121: 4575-4595. 195 002 IHC; tested species: mouse

Elevated expression of endogenous glial cell line-derived neurotrophic factor impairs spatial memory performance and raises inhibitory tone in the hippocampus.
Marshall P, Garton DR, Taira T, Võikar V, Vilenius C, Kulesskaya N, Rivera C, Andressoo JO
The European journal of neuroscience (2021) 538: 2469-2482. 195 002 IHC; tested species: mouse

Decoding the Transcriptional Response to Ischemic Stroke in Young and Aged Mouse Brain.
Androvic P, Kirdajova D, Tureckova J, Zucha D, Rohlova E, Abaffy P, Kriska J, Valny M, Anderova M, Kubista M, Valihrach L, et al.
Cell reports (2020) 3111: 107777. 195 002 IHC; tested species: mouse

Npas1+-Nkx2.1+ Neurons Are an Integral Part of the Cortico-pallido-cortical Loop.
Abecassis ZA, Berceau BL, Win PH, García D, Xenias HS, Cui Q, Pamukcu A, Cherian S, Hernández VM, Chon U, Lim BK, et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience (2020) 404: 743-768. 195 002 IHC; tested species: mouse

Semilunar granule cells are the primary source of the perisomatic excitatory innervation onto parvalbumin-expressing interneurons in the dentate gyrus.
Rovira-Esteban L, Hájos N, Nagy GA, Crespo C, Nacher J, Varea E, Blasco-Ibáñez JM
eNeuro (2020) : . 195 002 IHC; tested species: mouse

Region-specific interneuron demyelination and heightened anxiety-like behavior induced by adolescent binge alcohol treatment.
Rice J, Coutellier L, Weiner JL, Gu C
Acta neuropathologica communications (2019) 71: 173. 195 002 IHC; tested species: mouse

Ultrafast optogenetic stimulation of the auditory pathway by targeting-optimized Chronos.
Keppeler D, Merino RM, Lopez de la Morena D, Bali B, Huet AT, Gehrt A, Wrobel C, Subramanian S, Dombrowski T, Wolf F, Rankovic V, et al.
The EMBO journal (2018) : . 195 002 IHC; tested species: rat

The neuropathological investigation of the brain in a monkey model of autism spectrum disorder with ABCA13 deletion.
Iritani S, Torii Y, Habuchi C, Sekiguchi H, Fujishiro H, Yoshida M, Go Y, Iriki A, Isoda M, Ozaki N
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience (2018) : . 195 002 IHC; tested species: monkey

Intravenous infusion of human bone marrow mesenchymal stromal cells promotes functional recovery and neuroplasticity after ischemic stroke in mice.
Sammali E, Alia C, Vegliante G, Colombo V, Giordano N, Pischiutta F, Boncoraglio GB, Barilani M, Lazzari L, Caleo M, De Simoni MG, et al.
Scientific reports (2017) 71: 6962. 195 002 IHC; tested species: mouse

Damaged Neocortical Perineuronal Nets Due to Experimental Focal Cerebral Ischemia in Mice, Rats and Sheep.
Härtig W, Mages B, Aleithe S, Nitzsche B, Altmann S, Barthel H, Krueger M, Michalski D
Frontiers in integrative neuroscience (2017) 11: 15. 195 002 IHC; tested species: mouse,rat

Deletion of CTNNB1 in inhibitory circuitry contributes to autism-associated behavioral defects.
Dong F, Jiang J, McSweeney C, Zou D, Liu L, Mao Y
Human molecular genetics (2016) 2513: 2738-2751. 195 002 IHC

Abolished perineuronal nets and altered parvalbumin-immunoreactivity in the nucleus reticularis thalami of wildtype and 3xTg mice after experimental stroke.
Härtig W, Appel S, Suttkus A, Grosche J, Michalski D
Neuroscience (2016) 337: 66-87. 195 002 IHC

BDNF Depresses Excitability of Parvalbumin-Positive Interneurons through an M-Like Current in Rat Dentate Gyrus.
Nieto-Gonzalez JL, Jensen K
PloS one (2013) 86: e67318. 195 002 IHC

Cat. No.: 195 002

Amount: 200 µl

Price: $365.00

References
WB (2)
ICC (4)
IHC (21)

Long-Term Cultures of Spinal Cord Interneurons.
Vargova I, Kriska J, Kwok JCF, Fawcett JW, Jendelova P
Frontiers in cellular neuroscience (2022) 16: 827628. 195 002 ICC; tested species: mouse

Inhibition allocates spikes during hippocampal ripples.
Noguchi A, Huszár R, Morikawa S, Buzsáki G, Ikegaya Y
Nature communications (2022) 131: 1280. 195 002 IHC; tested species: mouse

BDNF Depresses Excitability of Parvalbumin-Positive Interneurons through an M-Like Current in Rat Dentate Gyrus.
Nieto-Gonzalez JL, Jensen K
PloS one (2013) 86: e67318. 195 002 IHC

IHC

IHC-P

Background

Parvalbumin is a small, acidic calcium binding protein and belongs to the family of EF hand proteins. The protein is found in skeletal muscle and the brain of vertebrates where it locates to a specific population of GABAergic interneurons. This subset of neurons may contribute to maintaining the balance between excitation and inhibition in the cortex and the hippocampus.

1 ) Andrioli A et al., Neuroscience (2007)
2 ) Hendrickson A et al., Exp. Eye Res. (2007)
3 ) Fukuda T et al., Neuroscience (2003)
4 ) Kosaka K et al., Exp Brain Res (1994)
5 ) Tolosa de Talamoni N et al., Proc. Natl. Acad. Sci. U.S.A. (1993)
6 ) Kubota Y et al., Neuroreport (1993)

Protocols

AP Detection
ECL Detection
Fluorescent detection
Pre-adsorption protocol

Standard protocol

IHC

Free floating
Slide mounted
Tissue preparation
Pre-adsorption protocol

IHC-P

Chromogenic detection
Fluorescent detection
Tissue preparation
Pre-adsorption protocol

OTHER

Preabsorbtion

Other products for this target

Parvalbumin antibody - 195 002

References for Parvalbumin - 195 002