Cat. No. 191 003 |
50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin and azide were added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use. Antibodies should be stored at +4°C when still lyophilized. Do not freeze! |
Applications | |
Immunogen | Recombinant protein corresponding to residues near the carboxy terminus of mouse mGluR1-α (UniProt Id: P97772) |
Reactivity |
Reacts with: mouse (P97772), rat (P23385). Other species not tested yet. |
Specificity | This antibody is specific for mGluR1-α and shows no cross-reactivity to mGluR1-β |
Remarks |
IHC: For best results, heat-mediated antigen retrieval (citrate buffer pH 6) is recommended. |
Data sheet | 191_003.pdf |
Glutamate is the main excitatory neurotransmitter in the vertebrate nervous system and regulates a number of cellular signaling pathways. In addition to the ionotropic glutamate receptors of the NMDA, AMPA and kainate type, eight metabotropic receptors (mGluR1-8) have been described so far (1). This receptor family can be subdivided into three groups (2): Group I receptors (mGluR1, mGluR5) are activated by dihydroxyphenylglycine (DHPG) (3), group II receptors (mGluR2, mGluR3) by dicarboxycyclopropylglycine (DCG-IV), and group III receptors (mGluR4, mGluR6, mGluR7, mGluR8) by aminophosphonobutyrate (L-AP4) (4).