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CASKIN 1 antibody - 185 003

CASKIN is a CASK interaction partner
Polyclonal rabbit purified antibody
Cat. No.: 185 003
Amount: 50 µg
Price: $450.00
Cat. No. 185 003 50 µg specific antibody, lyophilized. Affinity purified with the immunogen. Albumin was added for stabilization. For reconstitution add 50 µl H2O to get a 1mg/ml solution in PBS. Then aliquot and store at -20°C to -80°C until use.
Applications WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery  
IP: yes
ICC: 1 : 500 up to 1 : 1000 gallery  
IHC: 1 : 200 gallery  
IHC-P/FFPE: not tested yet
Immunogen Synthetic peptide corresponding to AA 1416 to 1430 from rat CASKIN1 (UniProt Id: Q8VHK2)
Specificity Specific for CASKIN 1.The epiotope is present in splice variants 1, 2, 3 but missing in variant 4. K.O. PubMed: 31727973
Matching control protein/peptide 185-0P
Data sheet 185_003.pdf

References for CASKIN 1 - 185 003

Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms.
Kim K, Shin W, Kang M, Lee S, Kim D, Kang R, Jung Y, Cho Y, Yang E, Kim H, Bae YC, et al.
eLife (2020) 9: . 185 003 WB; tested species: mouse
Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
Bencsik N, Pusztai S, Borbély S, Fekete A, Dülk M, Kis V, Pesti S, Vas V, Szűcs A, Buday L, Schlett K, et al.
Scientific reports (2019) 91: 16843. 185 003 WB; KO verified; tested species: mouse
Cat. No.: 185 003
Quantity: 50 µg
Price: $450.00
Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms.
Kim K, Shin W, Kang M, Lee S, Kim D, Kang R, Jung Y, Cho Y, Yang E, Kim H, Bae YC, et al.
eLife (2020) 9: . 185 003 WB; tested species: mouse
Dendritic spine morphology and memory formation depend on postsynaptic Caskin proteins.
Bencsik N, Pusztai S, Borbély S, Fekete A, Dülk M, Kis V, Pesti S, Vas V, Szűcs A, Buday L, Schlett K, et al.
Scientific reports (2019) 91: 16843. 185 003 WB; KO verified; tested species: mouse
Background

The complex of the multi-adaptor-proteins CASK, Veli and Mint is conserved across kingdoms. CASKIN 1 is a novel CASK interaction partner that binds to its Cam Kinase domain and competes with Mint so that alternative complexes can be formed. Four different splice variants have been identified so far.