|Cat. No. 185 002||200 µl antiserum, lyophilized. For reconstitution add 200 µl H2O, then aliquot and store at -20°C until use.|
WB: 1 : 1000 up to 1 : 5000 (AP staining) gallery
IP: not tested yet
ICC: 1 : 500 up to 1 : 1000 gallery
IHC-P/FFPE: not tested yet
|Immunogen||Synthetic peptide corresponding to AA 1416 to 1430 from rat CASKIN1 (UniProt Id: Q8VHK2)|
Reacts with: human (Q8WXD9), rat (Q8VHK2), mouse (Q6P9K8), cow, dog, monkey.
Other species not tested yet.
|Specificity||Specific for CASKIN 1.The epiotope is present in splice variants 1, 2, 3 but missing in variant 4.|
|Matching control protein/peptide||185-0P|
The complex of the multi-adaptor-proteins CASK, Veli and Mint is conserved across kingdoms. CASKIN 1 is a novel CASK interaction partner that binds to its Cam Kinase domain and competes with Mint so that alternative complexes can be formed. Four different splice variants have been identified so far.